Hematological picture of pediatric Sudanese patients with visceral leishmaniasis and prediction of leishmania donovani parasite load  

作　　者：Zeinab Ibrahim Ahmed Elnoor Omaima Abdelmajeed Alamin Mustafa Thuraya Gasim Shima Algam Mohamed Musa Abdelrahman Hamza Abdelmoneim Islamia Ibrahim Ahmed Omer Hiba Awadelkareem Osman Fadl 

机构地区：[1]Department of Pathology,Faculty of Medicine,Omdurman Ahilia University,Omdurman,Khartoum,Sudan [2]Mohammed Alamin Hamid Pediatric Hospital,Omdurman Khartoum,Sudan [3]Department of Hematology and Blood Transfusion Medicine,Federal Ministry of Health,Khartoum,Sudan [4]Department of Pediatrics,Faculty of Medicine,Omdurman Islamic University,Omdurman,Khartoum,Sudan [5]Tropical Diseases Teaching Hospital,Omdurman,Khartoum,Sudan [6]Faculty of Medicine,Al-Neelain University,Khartoum,Sudan [7]Faculty of Medicine,Omdurman Islamic University,Omdurman,Khartoum,Sudan [8]Department of Pediatrics,Faculty of Medicine,University of Science and Technology,Khartoum,Sudan [9]Department of Hematology,Faculty of Medical Laboratory Sciences,Al-Neelain University,Khartoum,Sudan

出　　处：《World Journal of Clinical Cases》2024年第30期6374-6382,共9页世界临床病例杂志

摘　　要：BACKGROUND Visceral leishmaniasis(VL)is a systemic protozoan infection caused by Leishmania donovani(L.donovani)and transmitted by sand flies,causing macrophage invasion in the liver,spleen,and bone marrow.Diagnosis of VL is currently based on clinical signs,symptoms,and specific in-vitro markers and bone marrow investigations.However,VL's specific hematological and bone marrow manifestation in Sudanese pediatric patients is not well studied.AIM To examine the blood and bone marrow characteristics in pediatric patients from Sudan who have VL.METHODS This is a retrospective hospital-based study with a sample of 107 consecutive Sudanese pediatric patients.The data focused on hematological and bone marrow results.We included only the completed records of the pediatric patients with VL in the Tropical Disease Teaching Hospital in Khartoum,Sudan from the period of 2016 to 2020.RESULTS The majority of pediatric patients included in this study are below 5-years-old(n=59,55.2%).Moreover,anemia,thrombocytopenia,and leukopenia were among the prevalent characteristics in the population under study.To further analyze the data,we developed a machine learning model using boosted forest algorithms to predict L.donovani parasites load,with a mean accuracy of 0.88 for the training dataset and an accuracy of 0.46,0.50,and 0.74 for mild,moderate,and severe L.donovani parasite load in the validation dataset.CONCLUSION This study shows that the most common bone marrow change among Sudanese VL children was increased chronic inflammatory cells(n=88,82.2%)with present macrophage hemophagocytes(n=103,96.3%).While anemia and thrombocytopenia were the most common hematological changes.These results will hopefully lead to an early diagnosis and hence better management for Sudanese pediatric patients with suspected VL.

关 键 词：Machine learning Bone marrow Hematological changes Tropical diseases Leishmania donovani Visceral leishmaniasis 

分 类 号：R531.6[医药卫生—内科学]