Clinical features of gastroesophageal reflux disease and erosive esophagitis:Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia  

作　　者：Firehiwot A Mengistie Abate B Shewaye Abel T Tasamma Zekarias S Ayalew 

机构地区：[1]Department of Internal Medicine,Addis Ababa University,Addis Ababa 1176,Addis Ababa,Ethiopia [2]Department of Internal Medicine,Rheum Rheumatology and Internal Medicine Specialty Clinic,Addis Ababa 1000,Addis Ababa,Ethiopia [3]Division of Gastroenterology and Hepatology,Department of Internal Medicine,Adera Medical and Surgical Center,Addis Ababa 1000,Addis Ababa,Ethiopia

出　　处：《World Journal of Gastroenterology》2024年第34期3883-3893,共11页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Gastroesophageal reflux disease(GERD)is a common disease worldwide with varying clinical presentations and risk factors.Prevalence data for Africa is lacking,but an increasing trend is expected due to demographic and epidemiological transitions.Although endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(EE),no studies in Ethiopia have investigated the clinical characteristics,risk factors,and severity of GERD using esophagogastroduodenoscopy(EGD).AIM To assess the clinical features of GERD in Ethiopian patients who underwent EGD and determine the severity and risk factors of EE.METHODS We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GERD and endoscopic findings of EE at Trauma Associated Severe Hemorrhage and Amniotic Membrane Stem Cell between January 2019 and August 2022.Data were collected from electronic medical records and phone call interviews.We used descriptive statistics and binary logistic regression analysis with SPSS version 26 to identify the association between variables with a statistical significance set at P value<0.05.RESULTS The mean±SD age of the patients was 44.8(±15.9)years,with a male-to-female ratio of 1.6:1.The most commonly reported symptom was epigastric pain(80.5%),followed by heartburn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of patients,followed by LA-B(14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or above,presence of bleeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe EE(P<0.05).Stricture and Barrett’s esophagus were observed in 4.5%and 1.36%of patients with EE,respectively.CONCLUSION Most of the patients had milder EE with fewer complications.However,severe EE was more prevalent in older patients and those with duodenitis/duodenopathy.

关 键 词：Gastroesophageal reflux disease Erosive esophagitis Hiatal hernia ESOPHAGOGASTRODUODENOSCOPY Heart burn 

分 类 号：R571[医药卫生—消化系统]