Gut microbiome:A revolution in typeⅡdiabetes mellitus  

作　　者：Madhan Jeyaraman Tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana 

机构地区：[1]Department of Orthopaedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [2]Department of Orthopaedics,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,São Paulo,Brazil [3]Department of Orthopaedics,Orthopaedic Research Group,Coimbatore 641045,Tamil Nadu,India [4]Department of Community Medicine,Government Stanley Medical College and Hospital,Chennai 600001,Tamil Nadu,India [5]Department of Orthopaedics,Government Medical College,Karur 639004,Tamil Nadu,India [6]Department of Biotechnology,Faculty of Engineering,Karpagam Academy of Higher Education,Coimbatore 641021,Tamil Nadu,India [7]Department of Orthopaedics,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India

出　　处：《World Journal of Diabetes》2024年第9期1874-1888,共15页世界糖尿病杂志（英文版）（电子版）

摘　　要：TypeⅡdiabetes mellitus(T2DM)has experienced a dramatic increase globally across countries of various income levels over the past three decades.The persistent prevalence of T2DM is attributed to a complex interplay of genetic and environmental factors.While numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse effects.In this context,the exploration of the gut microbiome presents a promising avenue.Research has increasingly shown that the gut microbiome of individuals with T2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and progression.This emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome transfer.These interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with T2DM.Although current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper investigation.Ongoing and future clinical trials are critical to advancing our understanding of the microbiome’s impact on diabetes.By further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted interventions.The potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of T2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关 键 词：TypeⅡdiabetes Gut microbiome PROBIOTICS PREBIOTICS Fecal microbiota transplantation 

分 类 号：R587.1[医药卫生—内分泌]