Recurrent stroke admissions with vs without COVID-19 and associated in-hospital mortality: A United States nationwide analysis, 2020  

作　　者：Rupak Desai Sai Priyanka Mellacheruvu Sai Anusha Akella Adil Sarvar Mohammed Mushfequa Hussain Abdul Aziz Mohammed Pakhal Saketha Praveena Sunkara Jyotsna Gummadi Paritharsh Ghantasala 

机构地区：[1]Outcomes Research,Independent Researcher,Atlanta,GA 30033,United States [2]Department of Public Health,University of Massachusetts,Lowell,MA 01854,United States [3]Department of Internal Medicine,One Brooklyn Health-Interfaith Medical Center,Brooklyn,NY 11213,United States [4]Department of Internal Medicine,Central Michigan University College of Medicine,Saginaw,MI 48602,United States [5]Department of Internal Medicine,Kamineni Institute of Medical Sciences,Narketpally 508254,India [6]Department of Internal Medicine,Bhaskar Medical College,Moinabad 500075,Hyderabad,India [7]Department of Internal Medicine,MedStar Medical Group,Charlotte Hall,MD 20622,United States [8]Department of Medicine,Medstar Franklin Square Medical Center,Baltimore,MD 21237,United States

出　　处：《World Journal of Virology》2024年第3期98-106,共9页世界病毒学杂志

摘　　要：BACKGROUND Coronavirus disease 2019(COVID-19)has been shown to increase the risk of stroke.However,the prevalence and risk of recurrent stroke in COVID-19 patients with prior stroke/transient ischemic attack(TIA),as well as its impact on mor-tality,are not established.AIM To evaluate the impact of COVID-19 on in-hospital mortality,length of stay,and healthcare costs in patients with recurrent strokes.METHODS We identified admissions of recurrent stroke(current acute ischemic stroke admissions with at least one prior TIA or stroke)in patients with and without COVID-19 using ICD-10-CM codes using the National Inpatient Sample(2020).We analyzed the impact of COVID-19 on mortality following recurrent stroke admissions by subgroups.RESULTS Of 97455 admissions with recurrent stroke,2140(2.2%)belonged to the COVID-19-positive group.The COVID-19-positive group had a higher prevalence of diabetes and chronic kidney disease vs the COVID-19 negative group(P<0.001).Among the subgroups,patients aged>65 years,patients aged 45–64 years,Asians,Hispanics,whites,and blacks in the COVID-19 positive group had higher rates of all-cause mortality than the COVID-19 negative group(P<0.01).Higher odds of in-hospital mortality were seen in the group aged 45-64(OR:8.40,95%CI:4.18-16.91)vs the group aged>65(OR:7.04,95%CI:5.24-9.44),males(OR:7.82,95%CI:5.38-11.35)compared to females(OR:6.15,95%CI:4.12-9.18),and in Hispanics(OR:15.47,95%CI:7.61-31.44)and Asians/Pacific Islanders(OR:14.93,95%CI:7.22-30.87)compared to blacks(OR:5.73,95%CI:3.08-10.68),and whites(OR:5.54,95%CI:3.79-8.09).CONCLUSION The study highlights the increased risk of all-cause in-hospital mortality in recurrent stroke patients with COVID-19,with a more pronounced increase in middle-aged patients,males,Hispanics,or Asians.

关 键 词：COVID-19 SARS-CoV-2 Recurrent stroke MORTALITY HOSPITALIZATION COMORBIDITIES Acute ischemic stroke 

分 类 号：R563.1[医药卫生—呼吸系统]