磁共振IDEAL-IQ序列测量肝脏脂肪含量的可行性研究  

Research and application of IDEAL-IQ sequence of magnetic resonance imaging for fat content measurement

作　　者：吴佳芳 许乙凯[1] 罗婉莉 Wu Jiafang;Xu Yikai;Luo Wanli(Medical Imaging Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院影像诊断科,广州510515

出　　处：《现代仪器与医疗》2024年第4期67-75,共9页Modern Instruments & Medical Treatment

基　　金：国家自然科学基金(51937010)。

摘　　要：目的 探究IDEAL-IQ序列测量肝脏脂肪含量的准确性,以及影响测量准确性的因素。方法 利用GE DISCOVERY MR750 3.0T的单通道头线圈、八通道头线圈以及八通道腹部线圈,对配置的不同浓度的水脂混合溶液模体进行高参数扫描。在GE AW4.6工作站上进行多次脂肪含量测量,并对测量数值进行线性回归分析,讨论测量值与已知配置值的相关性,分析配置水脂混合模体在不同线圈中测量的准确性。结果 对于已知浓度的水脂混合溶液模型,IDEAL-IQ序列在三个线圈测量数据的一元线性回归讨论中,三个回归模型的P<0.0001,测量模型均在α=0.0001的水平上显著性明显,拟合较好,置信度达到99.99%。不同线圈在同参数扫描的情况下,由于信噪比不同,在图像中出现明显噪点,在使用小ROI测量时,会使得同一层面测量结果出现较大偏差。结论 IDEAL-IQ序列运用于脂肪含量的定量测量是可行可靠的,并且精准性较高。但扫描图像的质量对于测量稳定性以及准确性有影响,图像噪声越大则测量结果越不稳定,测量值的偏差越大。在临床扫描条件下,临床医师的测量应该采用适当ROI多点测量取平均值的方式进行肝脏脂肪含量的测量,同时还应该避开肝脏扫描层中的初始层及末端层。如果选取区域落于初始层及末端层,则可能会导致脂肪含量的过估计。Objective Evaluating the accuracy of the IDEAL-IQ sequence in measuring liver fat content and identifying the factors influencing measurement accuracy.Methods Using the single channel head coil,eight channel head coil,and eight channel abdominal coil of GE Discovery MR750 3.0T,high parameter scanning was performed on water lipid mixed solution models with dif ferent concentrations.Multiple fat content measurements were conducted on the GE AW4.6 workstation,and linear regression analysis was performed on the measured values to discuss the correlation between the measured values and known configuration values,and to analyze the accuracy of measuring the water fat mixture phantom in dif ferent coils.Results For the aqueous lipid mixture solution model with a known concentration,the IDEAL-IQ sequence was employed in the univariate linear regression analysis of data measured by three dif ferent coils.The P-values for the three regression models were all less than 0.0001,indicating significant differences at the α= 0.0001 level.The models demonstrated good fitting,achieving a confidence level of 99.99%.Scanning with the same parameters but dif ferent coils results in image noise due to varying signal-to-noise ratios.Using a small ROI for measurement can lead to substantial deviations in the results for the same slice.Conclusion The IDEAL-IQ sequence is feasible,reliable,and highly accurate for quantitative measurement of fat content.However,the quality of scanned images has an impact on measurement stability and accuracy.The greater the image noise,the more unstable the measurement results and the greater the deviation of the measurement values.Under clinical scanning conditions,clinical physicians should measure liver fat content by taking the average of appropriate ROI multi-point measurements,while also avoiding the initial and end layers in the liver scanning layer.If the selected area falls within the initial and final layers,it may lead to overestimation of fat content.

关 键 词：磁共振成像技术 IDEAL-IQ 脂肪含量测量 临床精准测量1 

分 类 号：TH77[机械工程—仪器科学与技术] R580[机械工程—精密仪器及机械]