中药人参对脓毒症"急性虚证"免疫抑制调节作用的研究现状与展望  

Current research status and prospects of ginseng's regulatory effect on immune dysfunction caused by"acute deficiency syndrome"of sepsis

作　　者：仲凯强 陈瑞 李俊 奚小土 Zhong Kaiqiang;Chen Rui;Li Jun;Xi Xiaotu(Department of Emergency,Guangdong Provincial Hospital of Chinese Medicine(the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,the Second Clinical Medical College of Guangzhou University of Chinese Medicine),Guangzhou 510120,Guangdong,China)

机构地区：[1]广东省中医院(广州中医药大学第二附属医院,广州中医药大学第二临床医学院)急诊科,广州510120

出　　处：《中华危重病急救医学》2024年第7期681-686,共6页Chinese Critical Care Medicine

基　　金：国家自然科学基金(82204936);广东省中医药局科研项目(20213007)。

摘　　要：脓毒症为急诊重症监护病房(ICU)最常见的危重症之一,目前被定义为感染引起的体内炎症免疫失调导致的危及生命的器官功能障碍。脓毒症免疫功能抑制在疾病发生发展过程中起到关键作用。脓毒症中医"急性虚证"理论与现代医学免疫抑制学说异曲同工。在"急性虚证"理论指导下,具有大补元气功效的中药人参常被用于脓毒症的临床治疗,以发挥重要的扶正补虚作用。本文详细介绍了脓毒症免疫功能障碍的病理生理机制及其与中医"急性虚证"的关联,总结了人参治疗免疫功能障碍的现代药理学研究现状,分析了人参对脓毒症免疫抑制治疗作用的相关研究进展和不足之处,并对未来研究发展方向提出了展望。Sepsis is a prevalent critical illness observed in emergency intensive care unit(ICU),characterized by life-threatening organ dysfunction caused by infection-induced inflammatory immune disorders in the body.The suppression of immune function plays a crucial role in the development and progression of sepsis.Traditional Chinese medicine theory of"acute deficiency syndrome"in sepsis shares similarities with the concept of"immunosuppression".According to this theory,ginseng is frequently utilized in clinical treatment of sepsis due to its ability to invigorate vitality and strengthen the body,playing a crucial role in tonifying deficiency and improving the overall health of patients.This paper provides a detailed discussion of the pathophysiological mechanisms of sepsis immune dysfunction and its correlation with"acute deficiency syndrome"in traditional Chinese medicine.It summarizes the current state of modern pharmacological research on ginseng's impact on the body's immune function,discusses relevant research progress and shortcomings regarding ginseng's therapeutic effects on immunosuppression in sepsis,and proposes future research directions.

关 键 词：脓毒症 人参 急性虚证 免疫功能障碍 

分 类 号：R285[医药卫生—中药学]