肠道菌群失调与脓毒性心肌病关系的研究进展  

Research progress on the relationship between the gut microbiota dysbiosis and sepsis-induced cardiomyopathy

作　　者：杨佳艳 於江泉[2] 郑瑞强[2] Yang Jiayan;Yu Jiangquan;Zheng Ruiqiang(Yangzhou Clinical College of Dalian Medical University,Yangzhou 225001,Jiangsu,China;Department of Intensive Care Unit,Northern Jiangsu People's Hospital,Yangzhou 225001,Jiangsu,China)

机构地区：[1]大连医科大学扬州临床学院,江苏扬州225001 [2]江苏省苏北人民医院重症医学科,江苏扬州225001

出　　处：《中华危重病急救医学》2024年第7期774-777,共4页Chinese Critical Care Medicine

基　　金：江苏省十四五医学重点学科建设单位(JSDW20221)。

摘　　要：脓毒症是指由宿主对感染反应失调导致的危及生命的器官功能障碍。脓毒性心肌病(SICM)作为脓毒症患者的严重并发症,是一种与心肌缺血无关的急性可逆性心功能障碍综合征,影响脓毒症的转归及预后。肠道菌群作为一个复杂的微生物系统,已经有研究证实其参与了冠心病、高血压、心力衰竭等多种心血管系统疾病的进展,同时与脓毒症的发生发展也相关。然而,目前针对肠道菌群与SICM之间关系的研究还很少。本文将目前有关肠道菌群与SICM关系的研究进展进行综述,旨在为临床治疗SICM提供新的思路。Sepsis is a life-threatening organ dysfunction caused by the host's dysfunctional response to infection.Sepsis-induced cardiomyopathy(SICM),as a serious complication of sepsis,is an acute reversible cardiac dysfunction syndrome unrelated to myocardial ischemia,which affects the outcome and prognosis of sepsis.As a complex microbial system,gut microbiota has been confirmed to be involved in the development of coronary heart disease,hypertension,heart failure and other cardiovascular diseases,and is also related to the occurrence and development of sepsis.However,there are few studies on the relationship between gut microbiota and SICM.This paper reviews the current research progress on gut microbiota and SICM,aiming at provide a new idea for clinical treatment of SICM.

关 键 词：脓毒症 脓毒症心肌病 肠道菌群 

分 类 号：R459.7[医药卫生—急诊医学]