丙炔醇转化为联烯的反应研究  

Research on the Generation of Allenes From Propargyl Alcohol

作　　者：唐梦蝶 吕健 Tang Mengdie;Lyu Jian(Qingdao University of Science and Technology,College of Chemistry and Molecular Engineering,Qingdao 266044,China)

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266044

出　　处：《山东化工》2024年第16期40-43,共4页Shandong Chemical Industry

摘　　要：由于α-(对氨基苯基)丙炔醇是一类重要的合成前体,而其反应过程中的中间体联烯基中间体更是难以捕捉,因此捕捉此类化合物的中间体受到了广泛地关注。首次报道了在路易斯酸与磷酸二苯酯协同催化下,α-(对氨基苯基)丙炔醇在温和的条件下可以原位生成联烯酰胺中间体,并且产率可达90%。此方法验证了其化学活性,并据此确定了丙炔醇的活化模式。Due to the importance ofα-(p-aminophenyl)propargyl alcohol as a crucial synthetic precursor,and the difficulty in capturing the elusive allenyl intermediate during its reaction process,there has been widespread attention on capturing intermediates of such compounds.This paper reports,for the first time,that under the synergistic catalysis of a Lewis acid and diphenyl phosphate,α-(p-aminophenyl)propargyl alcohol can be in situ generated into an allenamide intermediate under mild conditions,with a yield of up to 90%.This method validates its chemical activity and thereby determines the activation mode of propargyl alcohol.

关 键 词：双酸催化 丙炔醇 联烯基酰胺中间体 共价活化模式 

分 类 号：O625.6[理学—有机化学]