银杏叶提取物联合前列地尔对慢性阻塞性肺疾病合并肺动脉高压患者的临床疗效  

Clinical effects of Ginkgo leaf extract combined with alprostadil on patients with chronic obstructive pulmonary disease complicated with pulmonary arterial hypertension

作　　者：陈红梅[1] 李洋[1] 王琦[2] 吴佳[2] 高国明[3] CHEN Hong-mei;LI Yang;WANG Qi;WU Jia;GAO Guo-ming(Department of Pharmacy,Tianshui Municipal Hospital of Integrated Traditional Chinese and Western Medicine,Tianshui 741020,China;Department of Respiratory and Critical Care Medicine,Tianshui Municipal Hospital of Integrated Traditional Chinese and Western Medicine,Tianshui 741020,China;Department of Interventional Therapy,Tianshui Municipal Hospital of Integrated Traditional Chinese and Western Medicine,Tianshui 741020,China)

机构地区：[1]天水市中西医结合医院药剂科,甘肃天水741020 [2]天水市中西医结合医院呼吸与危重症医学科,甘肃天水741020 [3]天水市中西医结合医院介入科,甘肃天水741020

出　　处：《中成药》2024年第9期2963-2967,共5页Chinese Traditional Patent Medicine

基　　金：甘肃省科技计划项目(21JR7RA671)。

摘　　要：目的探讨银杏叶提取物联合前列地尔对慢性阻塞性肺疾病合并肺动脉高压患者的临床疗效。方法122例患者随机分为对照组和观察组,每组61例,对照组给予前列地尔,观察组在对照组基础上加用银杏叶提取物,疗程3个月。检测临床疗效、肺功能指标(FVC、FEV_(1)、FEV_(1)/FVC)、血气指标(PaO_(2)、PaCO_(2))、PASP、mPAP、IL-6、ET-1、hs-CRP、NO、右心功能指标(RVEF、RVESD)、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组肺功能指标、PaO_(2)、RVESD升高(P<0.05),PaCO_(2)、IL-6、ET-1、hs-CRP、NO、RVEF降低(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论银杏叶提取物联合前列地尔可安全有效地改善慢性阻塞性肺疾病合并肺动脉高压患者肺功能和右心功能,减轻炎症反应。

关 键 词：银杏叶提取物 前列地尔 肺动脉高压 慢性阻塞性肺疾病 

分 类 号：R287[医药卫生—中药学]