二补助育汤调控子宫内膜容受性的临床和基础研究  

Clinical and basic research of regulating endometrial receptivity by Erbu Zhuyu Decoction

作　　者：刘雁峰[1] 强若男 江媚[2] 穆国华 石玥 梁嘉玲 周雨玫 郑志博 李影 邓楠 LIU Yanfeng;QIANG Ruonan;JIANG Mei;MU Guohua;SHI Yue;LIANG Jialing;ZHOU Yumei;ZHENG Zhibo;LI Ying;DENG Nan(Dongzhimen Hospital,Beijing University of Chinese Medicine,Bejing 100700,China;Beijing University of Chinese Medicine,Beijing 100029,China;Shuguang Hospital Affliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Haidian District Maternal and Child Health Care Hospital,Beijing 100080,China;Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Beijing University of Chinese Medicine Third Affliated Hospital,Beijing 100029,China;Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Hangzhou 310003,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学,北京100029 [3]上海中医药大学附属曙光医院,上海200021 [4]北京市海淀区妇幼保健院,北京100080 [5]上海交通大学医学院附属第九人民医院,上海200011 [6]北京中医药大学第三附属医院,北京100029 [7]浙江省中西医结合医院,杭州310003

出　　处：《中华中医药杂志》2024年第8期4050-4054,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82274567,No.82074480)。

摘　　要：随着女性生育需求的增加及辅助生殖技术的广泛应用,如何调控子宫内膜容受性成为生殖领域亟待解决的关键问题。国医大师肖承悰教授在改善子宫内膜容受性方面,独创“补肾气,通胞脉”之“二补助育汤”。临床研究结果显示二补助育汤及其改良方能改善中医证候、激素水平,增加内膜血流,改善内膜微环境,纠正血液高凝状态,促进内膜血管网建立与稳定,进而调控子宫内膜容受性。效应机制涵盖干细胞因子、整合素αⅤβ3、同源盒基因10、自噬、血管生成及氧化应激等多个靶点及相关信号通路,通过作用于胚胎着床过程中定位、黏附、侵入3个环节,对子宫内膜容受性产生调控作用。希冀为系统、科学地传承发扬燕京萧氏妇科的学术经验,提高临床妊娠率,助力中医药解决辅助生殖领域的难点问题,提供理论及实验依据。With the increasing demand for female fertility and the wide application of assisted reproduction technology,how to regulate endometrial receptivity has become a key issue in the field of reproduction that needs to be resolved urgently.In improving the endometrial receptivity,professor XIAO Chengcong,master of Chinese medicine originally creates the Erbu Zhuyu Decoction,which is designed to replenish the kidney qi and open the cytosolic veins'.Clinical studies have shown that Erbu Zhuyu Decoction and its improved formula can improve Chinese medicine symptoms and hormone levels,increase endometrial blood fiow,improve the endometrial microenvironment,correct the hypercoagulable state of the blood,promote the establishment and stability of the endometrial vascular network,and then regulate the endometrial receptivity.The mechanism of effect covers multiple targets and signalling pathways such as stem cell factor,integrinαVβ3,homobox gene 10,autophagy,angiogenesis,and oxidative stress,which regulate endometrial receptivity through the three links of localisation,adherence,and invasion of the follicle during the process of follicle implantation.We hope to provide theoretical and experimental basis for systematically and scientifically inheriting and developing the academic experience of Yanjing XIAOs'academic school of gynecology,improving the clinical pregnancy rate,and helping traditional Chinese medicine to solve the difficult problems in the field of assisted reproduction.

关 键 词：二补助育汤 子宫内膜容受性 燕京萧氏妇科 辅助生殖技术 体外受精-胚胎移植 中医药 

分 类 号：R271.9[医药卫生—中西医结合]