病证结合焦虑症动物模型研究思路探讨  

Analysis on the research ideas of animal models combining anxiety disorder with traditional Chinese medicine syndrome

作　　者：李琳 姚明利 石薪暖 刘玥芸 姜幼明 LI Lin;YAO Mingli;SHI Xinnuan;LIU Yueyun;JIANG Youming(School of Life Science,Beijing University of Chinese Medicine,Beijing 100029,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学生命科学学院,北京100029 [2]北京中医药大学中医学院,北京100029

出　　处：《中华中医药杂志》2024年第8期4200-4205,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.82074330)。

摘　　要：文章通过归纳分析现代医学常用焦虑症模型的分类、构建原理、方法和优缺点,焦虑症相关中医证候,总结中医病证结合焦虑症动物模型的构建方法和评价策略,并以慢性束缚应激-肝郁气滞证焦虑症为例,从模型构建原理、造模方法及工具优化、模型评价体系和模型应用角度,探讨病证结合焦虑症动物模型的研究思路和优越性。最后,针对目前病证结合焦虑症动物模型存在的不足提出新的展望,以期为中医药基础研究中病证结合动物模型的发展提供思路。In this paper,through summarizing and analyzing the classification,constructon principle,methods,advantages and disadvantages of anxity disorder models commonly used in modern medicine,and the related traditional Chinese medicine(TCM)syndromes of anxiety disorder,it is summarized the construction methods and evaluation strategies of the animal models combining anxiety disorder with TCM syndrome.Taking chronic restraint stress-liver depression and qi stagnation anxiety disorder as an example,exploring the research ideas and advantages of the animal models combining anxiety disorder with TCM syndrome from the aspects of model construction principle,modeling method and tool optimization,model evaluation system and model application.Finally,this paper puts forward new prospects for the shortcomings of the current animal models combining anxiety disorder with TCM syndrome,in order to provide ideas for the development of disease-syndrome combination animal models for basic research of traditional Chinese medicine.

关 键 词：病证结合 动物模型 焦虑症 肝郁气滞证 慢性束缚应激 

分 类 号：R277.7[医药卫生—中医学] R-332