泻痢康胶囊介导肠道菌群调控TNFR1/RIP1/ComplexⅠ信号通路治疗HIV/AIDS腹泻的机制探析  

Mechanism analysis of Xielikang Capsule mediated intestinal flora regulating TNFR1/RIP1/Complex I signaling pathway in treatment of HIV/AIDS diarrhea

作　　者：姜琦 许前磊[1,2,3] 郭会军 桑锋[1] 李鹏宇[1] JIANG Qi;XU Qianlei;GUO Huijun;SANG Feng;LI Pengyu(The First Affliated Hospital of Henan University of CM,Zhengzhou 450000,China;Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Key Laboratory of Viral Diseases Control with Chinese Medicine,Zhengzhou 450008,China)

机构地区：[1]河南中医药大学第一附属医院,郑州450000 [2]河南中医药大学,郑州450046 [3]河南省病毒性疾病中医药防治重点实验室,郑州450008

出　　处：《中华中医药杂志》2024年第8期4272-4276,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81873289,No.82274474);中原青年拔尖人才项目(No.ZYYCYU202012153);河南省中医药科学研究专项(No.2019JDZX2045);河南省科技攻关项目(No.232102311207)。

摘　　要：艾滋病腹泻是艾滋病患者常见的临床并发症,其病程长、缠绵难愈,严重影响了此类患者的工作与生活。艾滋病腹泻的发生与异常分泌的TNF-α激活RIP1/ComplexⅠ通路、肠黏膜屏障受损,菌群结构失衡相关。泻痢康胶囊能调节TNF-α分泌,修复肠黏膜屏障,调节菌群结构,减少CD_(4)^(+)T淋巴细胞的持续耗损,促进免疫机能修复。文章浅析泻痢康胶囊治疗艾滋病腹泻的作用机制,以期丰富其科学内涵。Diarrhea in AIDS is a prevalent clinical complication among AIDS patients.It has a protracted course,is persistent and refractory to treatment,seriously influencing the work and life of these patients.The occurrence of diarrhea in AIDS is associated with the abnormal secretion of TNF-αactivating the RIP1/Complex I pathway,the damaged intestinal mucosal barrier,and the imbalance of flora structure.Xielikang Capsule can regulate the secretion of TNF-α,repair the intestinal mucosal barrier,regulate the flora structure,reduce the continuous depletion of CD_(4)^(+)T lymphocytes,and promote the restoration of immune function.This article explores the mechanism of Xielikang Capsule in treating diarrhea in AIDS to further enrich its scientific connotation,with the anticipation of facilitating the research.

关 键 词：泻痢康胶囊 艾滋病相关腹泻 肠道菌群 TNFR1/RIP1/ComplexⅠ信号通路 

分 类 号：R285[医药卫生—中药学]