帕金森病初诊164例患者体质特点及与疾病严重程度的相关性分析  

Analysis of correlation between traditional Chinese medicine physique and disease severity in 164 patients with de novo Parkinson's disease

作　　者：李佩珊 刘卫国[1] 杨宁[1] 王海东[1] LI Peishan;LIU Weiguo;YANG Ning;WANG Haidong(The Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院,南京210029

出　　处：《中华中医药杂志》2024年第8期4450-4454,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：江苏省中医药管理局科技发展重点项目(No.2020ZX17);南京市医学科技发展项目(No.YKK20094);南京市中医药科技专项(No.ZYYB202206);南京医科大学校基金(No.NMUB20210234)。

摘　　要：目的:分析帕金森病(PD)初诊患者体质分布特征及与疾病严重程度的关系。方法:通过门诊调查问卷方式,采集164例PD初诊患者体质数据及UPDRS-Ⅲ评分、NMSQuest评分、H-Y分期,采用卡方检验、秩检验及Spearman相关分析等统计分析方法,分析单一体质分布规律、体质兼夹情况、体质与性别关系及体质与疾病严重程度的相关关系。结果:排名前4的异常体质(“是”和“倾向是”)在总样本的占比为阴虚(46.3%)、气虚(41.5%)、气郁(31.7%)和阳虚(29.3%);在各异常体质中,单一体质占比小,兼夹体质占比大;9种体质的男女分布无差异;9种体质中,阴虚、气虚、气郁、痰湿评分与疾严重病程度呈正相关,平和体质评分与疾病严重病程度呈负相关。结论:PD初诊患者体质以虚为主,最常见的体质类型为阴虚、气虚、气郁和阳虚,大部分兼夹其他体质,阴虚、气虚、气郁、痰湿体质评分和疾病严重程度密切正相关,初诊时需要重点关注调理这4种体质。Objective:To analyze the physiques distribution of patients with de novo Parkinson's disease(PD)and the relationship between traditional Chinese medicine(TCM)physique and disease severity.Methods:The physique data,UPDRSII score,NMSQuest score and H-Y staging of 164 patients with de novo PD were collected by outpatient questionnaire.Chisquare test,rank sum test and Spearman correlation analysis were used to reveal the distribution of single physique,compounded physique,the relationship between physique and sex,and the correlation between physique and disease severity.Results:The top four abnormal physiques(‘Yes'and‘tendency to be Yes')were yin deficiency(46.3%),qi deficiency(41.5%),qi stasis(31.7%)and yang deficiency(29.3%).Among abnormal physiques,the single physique had a small proportion,while the compounded physique had a large one.There was no difference in the distribution of 9 kinds of physique between men and women.The scores of yin deficiency,qi deficiency,qi stasis and phlegm-dampness physiques were positively correlated with the severity of disease,while the scores of peace physique was negatively correlated with the severity of disease.Conclusion:In patients with de novo PD,the most common types of physique were yin deficiency,qi deficiency,qi stagnation and yang deficiency,and most patients were compounded physiques.The scores of yin deficiency,qi deficiency,qi stasis and phlegm-dampness are closely and positively correlated with the severity of the disease.It should be noted that doctors pay more attention to patients with those four physiques in their outpatient services.

关 键 词：帕金森病 初诊 体质 疾病严重程度 UPDRS-Ⅲ评分 

分 类 号：R277.7[医药卫生—中医学]