二陈汤合菖蒲郁金汤加减对阻塞性睡眠呼吸暂停低通气综合征患者认知功能的影响  

Effects of Erchen Decoction and Changpu Yujin Decoction on cognitive function in obsctive sleep apnea-hypopnea syndrome patients

作　　者：张盼盼 李臣杰 邢彩耐 韩晓庆 黄超 王袁 王红阳 ZHANG Panpan;LI Chenjie;XING Cainai;HAN Xiaoqing;HUANG Chao;WANG Yuan;WANG Hongyang(North China University of Science and Technology Affiliated Hospital,Tangshan 063000,China)

机构地区：[1]华北理工大学附属医院,唐山063000

出　　处：《中华中医药杂志》2024年第8期4509-4512,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省中医药管理局科技计划项目(No.2022138)。

摘　　要：目的:探讨二陈汤合菖蒲郁金汤加减对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知功能的影响。方法:将90例OSAHS合并认知障碍的患者随机分为无创呼吸机组、中药治疗组及中药+无创呼吸机组,每组30例。治疗前后观察3组呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO_(2))、蒙特利尔认知评估量表(MoCA)评分、血清抑制羟自由基(·OH)及总抗氧化能力(TAOC)的变化。结果:治疗后,各组LSaO_(2)、MoCA评分、抑制·OH能力及TAOC较治疗前均显著升高(P<0.05),AHI均显著下降(P<0.05);与无创呼吸机组及中药治疗组治疗后比较,中药+无创呼吸机组LSaO_(2)、MoCA评分、抑制·OH能力及TAOC均显著升高(P<0.05),AHI均显著下降(P<0.05);与无创呼吸机组治疗后比较,中药治疗组LSaO_(2)、MoCA评分、抑制·OH能力及TAOC均显著下降(P<0.05),AHI显著升高(P<0.05)。结论:二陈汤合菖蒲郁金汤加减配合无创呼吸机有助于改善OSAHS患者的认知功能,其机制可能通过抑制氧化应激来实现。Objective:To investigate the effects of Erchen Decoction and Changpu Yujin Decoction on cognitive function in patients with obsctive sleep apnea-hypopnea syndrome(OSAHS).Methods:Ninety patients with OSAHS complicated with cognitive function impairment were randomly divided into non-invasive ventilator group,traditional Chinese medicine treatment group and traditional Chinese medicine+non-invasive ventilator group,with 30 cases in each group.The changes of apnea hypopnea index(AHI),minimum blood oxygen saturation(LSaO_(2)),Montreal Scale(MoCA)score,serum hydroxyl radical inhibition(·OH)and total antioxidant capacity(TAOC)were observed before and after treatment.Results:After treatment,LSaO,MoCA score,inhibition·OH ability and TAOC were increased(P<0.05),and AHI was decreased(P<0.05)in all groups compared with before treatment.Compared with non-invasive ventilator group and traditional Chinese medicine group after treatment,LSaO_(2),MoCA scores,inhibition·OH ability and TAOC in traditional Chinese medicine+non-invasive ventilator group were higher(P<0.05),and AHI was lower(P<0.05).Compared with non-invasive respiratory group after treatment,LSaO_(2),MoCA score,inhibition·OH ability and TAOC in Chinese medicine treatment group were lower(P<0.05),and AHI was higher(P<0.05).Conclution:Erchen Decoction and Changpu Yujin Decoction combined with non-invasive ventilator can improve cognitive function in patients with obstructive sleep apnea hypoventilation syndrome,and the mechanism may be realized by inhibiting oxidative stress.

关 键 词：二陈汤合菖蒲郁金汤加减 阻塞性睡眠呼吸暂停低通气综合征 总抗氧化能力 羟自由基 认知 

分 类 号：R276.1[医药卫生—中医五官科学]