2017-2022年中国急性弛缓性麻痹病例监测质量评价  

Quality of surveillance for acute flaccid paralysis cases in China,2017-2022

作　　者：周洁 樊春祥[2,3] 宋祎凡[2,3] 王淼[2,3] 温宁[2,3] 杨宏[2,3] Zhou Jie;Fan Chunxiang;Song Yifan;Wang Miao;Wen Ning;Yang Hong(Chinese Field Epidemiology Training Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China;National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Bejing 102206,China;National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention,Urumqi 830002,Xinjiang,China)

机构地区：[1]中国疾病预防控制中心中国现场流行病学培训项目,北京100050 [2]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [3]中国疾病预防控制中心免疫规划中心,北京100050 [4]新疆维吾尔自治区疾病预防控制中心,新疆乌鲁木齐830002

出　　处：《中国疫苗和免疫》2024年第4期403-408,共6页Chinese Journal of Vaccines and Immunization

基　　金：中国现场流行病学培训项目;中美疾控中心合作项目(6NU2GGH002164-05-07)。

摘　　要：目的评价中国急性弛缓性麻痹(Acute flaccid paralysis,AFP)病例监测质量和维持无脊髓灰质炎(脊灰)状态。方法通过中国AFP病例报告管理系统收集2017-2022年<15岁儿童非脊灰AFP个案信息,分析AFP监测敏感性和及时性指标。结果2017-2022年中国<15岁儿童非脊灰AFP病例年均报告发病率为2.08/10万(29116例),各年报告发病率在1.79/10万-2.33/10万之间;总调查及时率、合格粪便标本采集率分别为99.34%、92.12%,各年分别在98.79%-99.74%、91.48%-92.74%之间。在完成粪便标本检测的28765例AFP病例中,脊灰病毒和非脊灰肠道病毒分离率分别为0.55%(157例)、5.19%(1492例)。在检出脊灰病毒病例中,Ⅰ型、Ⅲ型、Ⅰ+Ⅲ型疫苗相似株分别为39例、70例、36例,Ⅲ型疫苗高变异脊灰病毒3例;Ⅰ型、Ⅱ型、Ⅲ型疫苗衍生脊灰病毒分别为2例、1例、6例,未发现脊灰野病毒。结论2017-2022年中国AFP病例监测质量总体良好,继续维持无脊灰状态。Objective To evaluate the quality of surveillance for acute flaccid paralysis(AFP)cases and polio-free status in China.Methods We obtained data on AFP cases under 15 years of age during 2017-2022 from the Chinese AFP Case Reporting Management System and analyzed performance indicators for the sensitivity and timeliness of AFP surveillance.Results The average annual incidence per 100000 population of reported non-polio AFP cases under 15 years of age was 2.08(a total of 29116 cases)during 2017-2022 in China,with incidences by year ranging from 1.79 to 2.33.Overall rates for timely AFP case investigation and for adequate stool specimen collection were 99.34%and 92.12%,respectively,ranging 98.79%to 99.74%and 91.48%to 92.74%by year.Among 28765 AFP cases with stool specimen detection,0.55%(157 cases)were positive to poliovirus and 5.19%(1492 cases)were positive to non-polio enterovirus.Poliovirus-positive cases included 39,70,and 36 cases of typeⅠ,Ⅲ,and typeⅠ+Ⅲvaccine-like strains;3 cases of typeⅢvaccine high-variant poliovirus strains;and 2,1,and 6 cases of typeⅠ,Ⅱ,andⅢvaccine-derived poliovirus strains.No wild poliovirus was found.Conclusion From 2017 to 2022,AFP surveillance was high-quality in China,maintaining polio-free status.

关 键 词：脊髓灰质炎 急性弛缓性麻痹 脊髓灰质炎病毒 监测 质量 

分 类 号：R186[医药卫生—流行病学]