甘肃省妊娠期接种流感疫苗预防孕妇流感样疾病保护效果的真实世界数据回顾性队列研究  

Effectiveness of influenza vaccination during pregnancy against influenza-like illness among pregnant women:a retrospective cohort study using real-world data in Gansu province

作　　者：梁雪枫[1] 彭娟霞 孙迪 张秉玲[1] 张晓曙[1] 安婧[1] 唐宇[1] Liang Xuefeng;Peng Juanxia;Sun Di;Zhang Bingling;Zhang Xiaoshu;An Jing;Tang Yu(Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省疾病预防控制中心,甘肃兰州730000

出　　处：《中国疫苗和免疫》2024年第4期432-435,共4页Chinese Journal of Vaccines and Immunization

基　　金：甘肃省卫生健康行业科研计划(GSWSKY2023-21)。

摘　　要：目的评价妊娠期接种流感疫苗(Influenza vaccine,InfV)预防孕妇流感样疾病(Influenza-like illness,ILI)的保护效果(Vaccine effectiveness,VE)。方法利用甘肃省电子病历系统和免疫规划信息系统构建2019-2021年流感流行季孕妇妊娠期接种InfV和分娩后6个月发生ILI的回顾性匹配队列,采用Log-binomial模型估计调整后VE及其95%置信区间(Confidence interval,CI)。结果妊娠期InfV接种组、未接种组孕妇ILI发病率分别为4.70%(54/1150)、6.91%(16990/245754),InfV接种预防孕妇ILI的调整VE为33.55%(95%CI:12.71%-49.41%)。结论甘肃省2019-2021年流感季妊娠期接种InfV预防孕妇ILI具有一定保护效果。Objective To evaluate the effectiveness of influenza vaccination during pregnancy against influenza-like illness(ILI)among pregnant women.Methods We used the Electronic Medical Record System and the Immunization Program Information System of Gansu province to construct a retrospective cohort data set of influenza vaccination during pregnancy in the 2019-2021 influenza seasons,matched within six months of delivery among pregnant women,testing for ILI.We estimated adjusted vaccine effectiveness(VE)and 95%confidence intervals(CI)using a log-binomial model.Results The incidence of ILI was 4.70%(54/1150)among pregnant women who received influenza vaccine(InfV)during pregnancy and 6.91%(16990/245754)among pregnant women who did not receive InfV.The adjusted InfV VE against ILI among pregnant women was 33.55%(95%CI:12.71%-49.41%).Conclusions Influenza vaccination during pregnancy during the 2029-2021 influenza season in Gansu showed significant effectiveness against ILI among pregnant women.

关 键 词：流感疫苗 妊娠期接种 流感样疾病 保护效果 孕妇 

分 类 号：R186[医药卫生—流行病学]