肠道病毒71型灭活疫苗研究进展  

Research progress towards enterovirus type 71 inactivated vaccines

作　　者：肖金波 史景红 严冬梅[1,2] 祝双利[1,2] 冀天娇 李雅静[3] 张勇[1,2] Xiao Jinbo;Shi Jinghong;Yan Dongmei;Zhu Shuangli;Ji Tianjiao;Li Yajing;Zhang Yong(National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Poliomyelitis Laboratory/WHO WPRO Regional Reference Laboratory for Poliomyelitis/National Health Commission Key Laboratory for Biosafety/National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Sinovac Biotech,Beijing 100085,China)

机构地区：[1]传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206 [2]国家脊髓灰质炎实验室,世界卫生组织西太平洋区脊髓灰质炎参比实验室,国家卫生健康委员会生物安全重点实验室,中国疾病预防控制中心病毒病预防控制所,北京102206 [3]北京科兴生物制品有限公司,北京100085

出　　处：《中国疫苗和免疫》2024年第4期492-500,共9页Chinese Journal of Vaccines and Immunization

摘　　要：肠道病毒71型(Enterovirus type 71,EV71)传染性较强,可引起儿童手足口病(Hand,foot and mouth disease,HFMD)、疱疹性咽颊炎和中枢神经系统感染等。中国EV71感染所致HFMD的疾病负担和经济负担较重,接种EV71疫苗是预防EV71感染最经济有效的措施,2015年12月EV71灭活疫苗获批上市后中国HFMD发病呈下降趋势。本文综述了近年来EV71疫苗上市前和上市后研究结果、接种EV71疫苗对HFMD的影响和处于研发阶段的含EV71成分疫苗,为EV71疫苗应用和含EV71成分多价疫苗研发提供参考。Enterovirus type 71(EV71) is a highly contagious virus that can generally cause hand, foot, and mouth disease(HFMD), herpangina, and central nervous system infections. The disease and economic burden of HFMD related to EV71 infection are heavy in China. EV71 vaccination is one of the most economical and effective measures against EV71 infection. The incidence of HFMD in China has decreased since inactivated EV71 vaccines were licensed in December 2015. In this article, we describe pre-and post-marketing research result from EV71 vaccination, the impact of EV71 vaccination on HFMD, and other EV71-containing vaccines under development to provide reference for the use of EV71 vaccine and promote research and development of multivalent EV71-containing vaccines.

关 键 词：肠道病毒71型 手足口病 肠道病毒71型灭活疫苗 研究进展 

分 类 号：R186[医药卫生—流行病学]