滑膜间充质干细胞修复软骨损伤的研究进展  

Research progress on synovial mesenchymal stem cells to repair cartilage damage

作　　者：李林臻 刘琪 焦泓焯 张君涛[1,2] LI Lin-zhen;LIU Qi;JIAO Hongzhuo;ZHANG Jun-tao(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine,Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]国家中医针灸临床医学研究中心,天津300381

出　　处：《中国矫形外科杂志》2024年第16期1486-1491,共6页Orthopedic Journal of China

基　　金：国家自然科学基金资助项目(编号:82074470)。

摘　　要：软骨是关节的重要结构,在关节腔内起润滑关节、缓冲压力的作用。软骨损伤会导致膝骨关节炎(knee osteoarthritis,KOA),严重影响患者的生活质量。目前临床用于治疗KOA的手段并不能修复受损软骨。近年来,滑膜间充质干细胞(synovial mesenchymal stem cells,SMSCs)以其在软骨损伤修复方面的独特优势,成为修复受损软骨的热点研究领域。本文对SMSCs修复软骨损伤的机制及体内外研究进展进行综述,以期推动SMSCs修复软骨损伤向临床转化。Cartilage is an important structure of joint,and plays role in lubricating the joint and cushioning pressure within the joint cavity.Cartilage injury can lead to knee osteoarthritis(KOA),severely affecting patients'quality of life.Current clinical methods used to treat KOA cannot repair damaged cartilage.In recent years,synovial mesenchymal stem cells(SMSCs)have shown unique advantages in repairing cartilage injuries,making it a hot research field for cartilage repair.Therefore,this article provides a comprehensive review of the mechanisms and research progress of SMSCs in repairing cartilage injuries,with the aim of promoting the clinical translation of SMSCs in cartilage repair.

关 键 词：滑膜间充质干细胞 膝骨关节炎 软骨损伤 软骨修复 

分 类 号：R683[医药卫生—骨科学]