Observational study:efficacy of aspirin and low-molecular-weight heparin in the management of recurrent miscarriage  

低分子肝素联合小剂量阿司匹林在复发性流产治疗中的应用价值研究

作　　者：Yuehong Tang Ting Wang Ai-e Cao Huizhi Lian Chunping Qiu 唐跃虹;王婷;曹爱娥;莲慧芝;邱春萍(海南妇产科医院妇产科,海南海口570100)

机构地区：[1]Department of Gynaecology and Obstetrics,Hainan Obstetrics and Gynecology Hospital,Haikou 570100,Hainan,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2024年第8期730-736,共7页中国药学（英文版）

基　　金：Hainan Province Health Industry Research Project(Grant No.20A200520).

摘　　要：In the present study,we aimed to assess the comparative efficacy of low-molecular-weight heparin(LMWH)in combination with low-dose aspirin for the management of recurrent miscarriage and scrutinize alterations in coagulation function following such treatment.A retrospective analysis was conducted on clinical data obtained from 97 patients with recurrent miscarriage treated at our institution from January 2019 to June 2020.Patients were categorized into either the study or control groups based on the administration of LMWH.The control group comprised 48 patients treated solely with aspirin,while the study group included 49 patients treated with both LMWH and aspirin.Comparative evaluations between the two groups encompassed pregnancy outcomes,coagulation function,adverse reactions,and blood loss during delivery.Results revealed a higher term birth rate in the study group(83.67%)compared to the control group(50%).Post-treatment,the study group exhibited lower prothrombin time,plasminogen activator inhibitor,and D-dimer levels than the control group.Moreover,the study group experienced fewer adverse reactions and reduced blood loss during delivery in comparison to the control group,demonstrating statistical significance(P<0.05).The combination of LMWH and low-dose aspirin exhibited noteworthy application in the management of recurrent miscarriage.This therapeutic approach not only fostered the enhancement of coagulation function conducive to pregnancy but also diminished the incidence of adverse reactions observed with aspirin alone.本研究旨在比较低分子肝素联合小剂量阿司匹林在复发性流产治疗中的应用价值,分析低分子肝素联合小剂量阿司匹林治疗后凝血功能变化。回顾性分析2019年1月至2020年6月在我院保胎治疗的97例复发性流产患者的临床资料,根据是否联合低分子肝素治疗将患者分为研究组和对照组,单用阿司匹林治疗的患者48例为对照组,低分子肝素联合阿司匹林治疗的患者49例为研究组,比较两组患者妊娠结局、凝血功能、不良反应、分娩出血量。结果表明研究组足月产率(83.67%)高于对照组足月产率(50%),治疗后研究组凝血酶原时间、纤溶酶原激活剂抑制物、D-二聚体均低于对照组,研究组不良反应、分娩时的出血量少于对照组,差异均有统计学意义(P<0.05)。低分子肝素联合小剂量阿司匹林在复发性流产治疗中有一定的应用价值,联合低分子肝素的应用不仅能使凝血功能向有利于妊娠的方向发展,还能降低单用阿司匹林的不良反应发生率。

关 键 词：Recurrent miscarriage Low-molecular-weight heparin ASPIRIN Full production Coagulation function 

分 类 号：R979[医药卫生—药品]