洛阳市孟津区健康人群乙型病毒性肝炎血清流行病学调查  

Seroepidemiological survey of hepatitis B among healthy population in Mengjin district,Luoyang city

作　　者：张露露 韩琳[1] 杨闪[1] 刘帅 ZHANG Lu-lu;HAN Lin;YANG Shan;LIU Shuai(Luoyang Municipal Center for Disease Control and Prevention,Luoyang,Henan 471023,China)

机构地区：[1]河南省洛阳市疾病预防控制中心,河南洛阳471023

出　　处：《疾病预防控制通报》2024年第4期43-46,共4页Bulletin of Disease Control & Prevention(China)

摘　　要：目的了解洛阳市孟津区人群乙型肝炎(乙肝)病毒(HBV)血清标志物阳性率。方法采用多阶段分层抽样的方法,于2021年洛阳市孟津区选取1~79岁人群进行问卷调查和血清标本采集。采用酶联免疫吸附法(ELISA)检测血清标本中乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)和乙肝核心抗体(HBcAb),对HBsAg阳性者检测其乙肝e抗原(HBeAg)和乙肝e抗体(HBeAb),分析血清标志物阳性率。结果630名调查对象的HBsAg、HBsAb、HBcAb阳性率分别为1.75%、60.48%、18.25%;HBsAg阳性者中,HBeAg阳性占9.09%,HBeAb阳性占81.82%。HBsAg阳性率40~79岁组最高(4.12%)、1岁~组和5岁~组最低(0.00%),不同年龄组HBsAg阳性率差异有统计学意义(P=0.005);HBsAb阳性率1岁~组最高(92.50%)、5岁~组最低(44.12%),不同年龄组HBsAb阳性率差异有统计学意义(χ^(2)=72.016,P<0.001)。HBsAb阳性率随末剂乙肝疫苗接种时间的增加而下降(χ^(2)=84.961,P<0.001)。结论洛阳市孟津区儿童HBV感染率较低,但成人中仍然存在HBV感染者;应在保持儿童乙肝疫苗常规免疫工作质量的同时,加强青少年和成人的乙肝疫苗接种工作。Objective To understand the positive rates of the serum markers of Hepatitis B virus(HBV)in the people living in Mengjin district of Luoyang city.Methods The questionnaire survey and blood samples were carried out in the selected people aged 1-79 years with multi-stage cluster random sampling method in Mengjin district of Luoyang city,2021.The surface antigen(HBsAg),surface antibody(HBsAb)and core antibody(HBcAb)of HBV in serum samples were tested with enzyme-linked immunosorbent assay(ELISA)method.If HBsAg was positive,the e antigen(HBeAg)and e antibody(HBeAb)of HBV were tested in the serum sample.Then the positive rate of the markers in the serum were be analyzed.Results The positive rate of HBsAg,HBsAb and HBcAb was 1.75%,60.48%and 18.25%,respectively in 630 subjects.Among the subjects with HBsAg positive,the positive rate of HBeAg and HBeAb was 9.09%and 81.82%.The positive rate of HBsAg was the highest in the age group of 40-79 years(4.12%),and the lowest in the age group of 1-years and 5-years(0.00%).There was statistical difference among the positive rates of HBsAg in different age groups(P=0.005).The positive rate of HBsAb was the highest in the age group of 1-years(92.50%),and the lowest in the age group of 5-years(44.12%).There was statistical difference among the positive rates of HBsAb in different age groups(χ^(2)=72.016,P<0.001).The positive rates of HBsAb decreased as the inoculation time of final dose of hepatitis B vaccine lengthening(χ^(2)=84.961,P<0.001).Conclusions The infection rate of HBV is relatively low in children in Mengjin district of Luoyang city.The adult HBV infectors stil exist.The quality of routine immunization of Hepatitis B vaccine should be maintained in children,meanwhile vaccination of hepatitis B should be enhanced in adolescents and adults.

关 键 词：乙型肝炎 乙型肝炎病毒 乙型肝炎疫苗 血清标志物 阳性率 

分 类 号：R512.62[医药卫生—内科学]