脂质组学在急性呼吸窘迫综合征中的应用和临床进展  

Application and research progress of lipidomics in acute respiratory distress syndrome

作　　者：孙藏岚 黄丽丽[1] 李小雨 邱海波[1] Canglan Sun;Lili Huang;Xiaoyu Li;Haibo Qiu(Jiangsu Provincial Key Laboratory of Critical Care Medicine,Zhongda hospital,School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]江苏省重症医学重点实验室,东南大学附属中大医院重症医学科,南京210009

出　　处：《中华重症医学电子杂志》2024年第2期127-135,共9页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：基金资助:国家自然科学基金重点项目(82341032);科技部国家重点研发计划项目(2022YFC2504400)。

摘　　要：急性呼吸窘迫综合征(ARDS)是以顽固性低氧血症为特征、严重威胁患者生命的肺部疾病。脂质组学是对生物、组织或细胞内脂质及与脂质相互作用的因素进行系统性分析的新兴学科,其在疾病发生及诊断中的作用受到越来越多的重视。近年来,许多基于脂质组学筛选出的代谢产物被提出可作为潜在的生物标志物,用于评估ARDS的早期发展及预后,并为新的靶向干预措施提供依据。本文对脂质组学在ARDS发病机制、诊断、异质性、预后及治疗中的应用进行综述。Acute respiratory distress syndrome(ARDS)is a life-threatening lung disease characterized by intractable hypoxemia.Lipidomics is a new subject for systematic analysis of lipids in organisms,tissues or cells and factors interacting with lipids.More and more attention has been paid to its role in the occurrence and diagnosis of diseases.In recent years,many metabolites screened based on lipidomics have been proposed as potential biomarkers to evaluate the early development and prognosis of ARDS,and provide a basis for new targeted interventions.We reviewed the application of lipidomics in the pathogenesis,diagnosis,heterogeneity,prognosis and treatment of ARDS in this review.

关 键 词：脂质组学 急性呼吸窘迫综合征 应用 

分 类 号：R563.8[医药卫生—呼吸系统]