基于临床实践指南/专家共识的乙型肝炎预防策略知识图谱构建  

Construction knowledge graphs of hepatitis B prevention strategies based on clinical practice guidelines/expert consensus

作　　者：刘雅菲 李颖 程千吉 黄嘉杰 李盛 葛龙 Liu Yafei;Li Ying;Cheng Qianji;Huang Jiajie;Li Sheng;Ge Long(School of Public Health,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Evidence Based Medicine of Gansu Province,Lanzhou 730000,China;WHO Collaborating Center for Guideline Implementation and Knowledge Translation,Lanzhou 730000,China;School of Nursing,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Lanzhou Pulmonary Hospital/Gansu Infectious Hospital/Gansu Public Health Medical Treatment Center,Lanzhou 730046,China)

机构地区：[1]兰州大学公共卫生学院,甘肃兰州730000 [2]甘肃省循证医学重点实验室,甘肃兰州730000 [3]世界卫生组织指南实施与知识转化合作中心,甘肃兰州730000 [4]甘肃中医药大学护理学院,甘肃兰州730000 [5]兰州市肺科医院甘肃省传染病医院甘肃省公共卫生医疗救治中心,甘肃兰州730046

出　　处：《兰州大学学报（医学版）》2024年第7期60-72,共13页Journal of Lanzhou University（Medical Sciences）

基　　金：中国中医科学院科技创新工程资助项目(CI2021A05502)。

摘　　要：目的探讨不同人群乙型肝炎(乙肝)预防策略之间的关联,为乙肝预防的决策制定和实践提供科学依据。方法检索国内外乙肝指南和专家共识,提取乙肝预防推荐意见并抽取实体、关系和属性数据,利用Python的py2neo库调用数据,将其导入Neo4j图数据库中构建可视化知识图谱。结果检索8个数据库和12个官方网站,共获得中文指南6部、专家共识2部,英文指南16部、专家共识2部,提取了260条预防相关推荐意见。根据推荐意见抽取得到适用人群、特殊人群、检测类操作、干预类操作、药物大类、具体药物名称、时机和推荐程度共8种实体,以及操作选择、最佳操作时间、用药选择、用药时间、进行和包含共6种关系,最终构建了筛查、疫苗接种、母婴阻断、管理策略和暴露后预防共5个知识图谱,为不同人群提供相应的乙肝预防策略。结论乙肝预防策略知识图谱的构建有助于医疗工作者和公众更好地了解乙肝预防措施,为决策者制定更具针对性和有效性的乙肝防控策略提供科学依据,促进乙肝防控工作的全面展开和持续发展。Objective To explore the association between hepatitis B prevention strategies in different populations and to provide a scientific basis for decision-making and practice in this field.Method Through a retrieval of Chinese and international hepatitis B guidelines and expert consensus,recommendations for hepatitis B prevention were extracted along with the entity,relationship and attribute data.Subsequently,via the py2neo library in Python the data was imported into the Neo4j graph database to build visual knowledge graphs.Results A total of 8 databases and 12 official websites were searched,resulting in an acquisition of 6 Chinese guidelines,2 Chinese expert consensuses,16 English guidelines and 2 English expert consensuses,from which 260 prevention-related recommendations were extracted.Based on them,8 entities including population,special populations,virus-testing operations,medical interventions,drug classes,specific drug names,timing and level of recommendation were extracted,along with 6 types of relationships such as operation selection,optimal timing of operations,medication selection,timing of medication,implement,and inclusion.Ultimately,knowledge graphs for screening,vaccination,mother-to-child transmission prevention,management strategies,and post-exposure prevention were constructed to provide corresponding hepatitis B prevention strategies for different population groups.Conclusion The construction of the hepatitis B prevention strategy knowledge graphs facilitates healthcare workers and the public in better understanding hepatitis B prevention measures.It also provides a scientific basis for decision-makers to formulate more targeted and effective hepatitis B prevention and control strategies,thereby promoting comprehensive and sustainable development in hepatitis B prevention and control efforts.

关 键 词：乙型肝炎 知识图谱 筛查 疫苗接种 母婴阻断 管理策略 暴露后预防 

分 类 号：R512.62[医药卫生—内科学] R183[医药卫生—临床医学]