肺部微生物对心血管疾病的影响  

Impact of pulmonary microbiome on cardiovascular disease

作　　者：张梦洁 陈薇 卢恒 王小花 王爱平 冯荣 Zhang Mengjie#;Chen Wei#;Lu Heng;Wang Xiaohua;Wang Aiping;Feng Rong(Hengyang Medical College,University of South China,Hengyang 421001,Hunan,China;Cardiovascular Department of Changsha First Hospital,Changsha 410005,China)

机构地区：[1]南华大学衡阳医学院,湖南衡阳421001 [2]长沙市第一医院心血管内一科,湖南长沙410005

出　　处：《兰州大学学报（医学版）》2024年第7期80-86,共7页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金资助项目(81600040)。

摘　　要：肺部微生物对人类健康和疾病起重要作用,可通过氧化应激、免疫炎症和补体形成等多种机制对心血管疾病的发生发展产生促进作用,导致心血管疾病恶化,甚至威胁生命。本文综述肺部微生物的起源、进展、现状、组成和主要生理功能及其对心血管疾病的影响,为调控肺部微生物的抗心血管疾病策略提供新的理论依据,围绕肺部微生物的作用机理为心血管疾病的防治提供新的治疗靶点、拓展新思路。Lung microbes play an important role in human health and disease,pulmonary microorganisms can promote the occurrence and development of cardiovascular diseases through various mechanisms such as oxidative stress,immune inflammation and complement formation,leading to a deterioration of cardiovascular diseases and even threatening life.This paper reviewed the origin,progress and status quo of pulmonary microorganisms,the composition and main physiological functions of pulmonary microorganisms,and the impact of pulmonary microbial abnormalities on cardiovascular diseases,so as to provide a new theoretical basis for anti-cardiovascular disease strategies based on a regulation of pulmonary microorganisms.It could also provide new therapeutic targets and develop new ideas for the prevention and treatment of cardiovascular diseases by centering on the mechanism of pulmonary microorganisms.

关 键 词：肺部微生物 心血管疾病 肺炎链球菌 肺炎衣原体 严重急性呼吸系统综合征冠状病毒2 肺炎支原体 

分 类 号：Q935[生物学—微生物学]