火针联合活血化瘀汤对血瘀型寻常型银屑病患者疾病严重程度、皮肤屏障功能及血液流变学的影响  

Impacts of fire needling combined with Huoxue Huayu Decoction on disease severity,skin barrier function and hemorheology in patients with psoriasis vulgaris of blood stasis syndrome

作　　者：王艳心 赵娜 安骏腾 WANG Yanxin;ZHAO Na;AN Junteng(Department of Dermatology,Cangzhou Integrated Hospital of Traditional Chinese and Western Medicine,Cangzhou,Hebei,061000)

机构地区：[1]河北省沧州中西医结合医院皮肤科,河北沧州061000

出　　处：《实用临床医药杂志》2024年第16期65-69,共5页Journal of Clinical Medicine in Practice

基　　金：河北省中医药管理局资助项目(2022230)。

摘　　要：目的探讨火针联合活血化瘀汤对血瘀型寻常型银屑病患者疾病严重程度、皮肤屏障功能及血液流变学的影响。方法选取在本院接受治疗的120例血瘀型寻常型银屑病患者为研究对象,按照随机数字表法分为中药组(60例)和联合组(60例)。比较2组中医证候积分,严重程度[皮损面积严重指数(PASI)评分],血液流变学(全血低切黏度、全血高切黏度、血浆黏度),皮肤屏障功能(经表皮水分丢失、角质层含水量及皮脂含量),生活质量[皮肤病生活质量指数(DLQI)评分]及临床疗效。结果与治疗前比较,2组治疗后皮损肥厚浸润、皮损颜色、瘙痒、肌肤甲错各项中医证候积分、PASI评分、全血低切黏度、全血高切黏度、血浆黏度、经表皮水分丢失及DLQI评分降低,且与中药组比较,联合组降低程度更显著,差异有统计学意义(P<0.05);与治疗前比较,2组治疗后角质层含水量及皮脂含量升高,且联合组高于中药组,差异有统计学意义(P<0.05);联合组总有效率为93.33%,高于中药组的78.33%,差异有统计学意义(P<0.05)。结论火针联合活血化瘀汤治疗血瘀型寻常型银屑病可有效改善患者临床症状及皮肤屏障功能,调节血液流变学指标,提高生活质量。Objective To investigate the impacts of fire needling combined with Huoxue Huayu Decoction on disease severity,skin barrier function and hemorheology in patients with psoriasis vulgaris of blood stasis syndrome.Methods A total of 120 patients with psoriasis vulgaris of blood stasis syndrome treated in our hospital were randomly divided into traditional Chinese medicine group(60 cases)and combined group(60 cases)according to the random number table method.The TCM syndrome scores,severity[Psoriasis Area and Severity Index(PASI)score],hemorheology(whole blood low shear viscosity and high shear viscosity,plasma viscosity),skin barrier function(transepidermal moisture loss,stratum corneum water content and sebum content),quality of life[Dermatology Life Quality Index(DLQI)score]and clinical healing effect were compared.Results Compared with before treatment,the scores of TCM syndromes such as hypertrophic infiltration of skin lesions,skin lesion color,pruritus,and skin dryness,PASI score,whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,transepidermal water loss and DLQI score in both groups were decreased after treatment,and the degree of reduction in the combined group was more significant than that in the traditional Chinese medicine group(P<0.05).Compared with before treatment,the water content and sebum content of the stratum corneum in both groups increased after treatment,and the combined group was higher than the traditional Chinese medicine group(P<0.05).The total effective rate of the combined group was 93.33%,which was higher than 78.33%of the traditional Chinese medicine group(P<0.05).Conclusion Fire needling combined with Huoxue Huayu Decoction for psoriasis vulgaris of blood stasis syndrome can usefully ameliorate the clinical symptoms and skin barrier function,regulate blood rheologyindexes,and enhance the quality of life.

关 键 词：寻常型银屑病 活血化瘀汤 火针 血液流变学 全血低切黏度 全血高切黏度 

分 类 号：R246.7[医药卫生—针灸推拿学] R245[医药卫生—中医临床基础] R28[医药卫生—中医学]