司美格鲁肽联合二甲双胍对2型糖尿病患者血清载脂蛋白B与载脂蛋白A1比值、网膜素-1及成纤维细胞生长因子-21的影响  

Effect of semaglutide combined with metformin on ratio of serum apolipoprotein B to apolipoprotein A1,omentin-1 and fibroblast growth factor-21 in patients with type 2 diabetes mellitus

作　　者：李霞 姚涛 王颖 LI Xia;YAO Tao;WANG Ying(Department of Endocrinology,Tangshan Nanhu Hospital,Tangshan,Hebei,063000)

机构地区：[1]河北省唐山南湖医院内分泌科,河北唐山063000

出　　处：《实用临床医药杂志》2024年第16期83-87,共5页Journal of Clinical Medicine in Practice

基　　金：河北省卫生健康委科研项目(2022HK0265)。

摘　　要：目的探讨司美格鲁肽联合二甲双胍对2型糖尿病(T2DM)患者血清载脂蛋白B与载脂蛋白A1比值(ApoB/ApoA1)、网膜素-1(Omentin-1)、成纤维细胞生长因子-21(FGF-21)水平的影响。方法选取86例T2MD患者为研究对象,采用随机数字表法分为对照组(二甲双胍治疗)和观察组(司美格鲁肽联合二甲双胍治疗)。比较2组治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白、血脂指标、胰岛素自身抗体(IAA)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)及ApoB/ApoA1、Omentin-1、FGF-21水平,以及不良反应发生情况。结果治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组HOMA-IR、IAA低于对照组,HOMA-β高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清Omentin-1水平高于对照组,ApoB/ApoA1、FGF-21水平低于对照组,差异有统计学意义(P<0.05)。对照组发生1例腹泻,2例便秘,不良反应总发生率为6.98%;观察组发生低血糖、腹泻各1例,不良反应总发生率为4.65%;2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论司美格鲁肽联合二甲双胍能有效控制T2MD患者血糖和血脂水平,提高Omentin-1水平,降低ApoB/ApoA1、FGF-21水平。Objective To investigate the effect of semaglutide combined with metformin on the ratio of apolipoprotein B to apolipoprotein A1(ApoB/ApoA1),omentin-1and fibroblast growth factor-21(FGF-21)levels in patients with type 2 diabetes mellitus(T2DM).Methods A total of 86 patients with T2DM were selected as research objects and randomly divided into control group(treated with metformin)and observation group(treated with semaglutide and metformin).The fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,blood lipid indicators,insulin autoantibody(IAA),insulin resistance index(HOMA-IR),pancreaticβ-cell function index(HOMA-β),ApoB/ApoA1,omentin-1,and FGF-21 levels before and after treatment were compared between the two groups.The occurrence of adverse reactions in both groups was also compared.Results After treatment,the fasting blood glucose,2-hour postprandial blood glucose,and glycated hemoglobin levels in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the total cholesterol,triglycerides,and low-density lipoprotein cholesterol levels in the observation group were significantly lower than those in the control group,while the high-density lipoprotein cholesterol level was significantly higher than that in the control group(P<0.05).After treatment,the HOMA-IR and IAA in the observation group were significantly lower than those in the control group,while the HOMA-βwas significantly higher than that in the control group(P<0.05).After treatment,the serum omentin-1 level in the observation group was significantly higher than that in the control group,while the ApoB/ApoA1 and FGF-21 levels were significantly lower than those in the control group(P<0.05).In the control group,there were 1 case of diarrhea and 2 cases of constipation,with a total incidence of adverse reactions of 6.98%;in the observation group,there were 1 case of hypoglycemia and 1 case of diarrhea,with a total incidence of adverse reactions of 4.65%;there was no significant differ

关 键 词：司美格鲁肽 二甲双胍 2型糖尿病 载脂蛋白B 载脂蛋白A1 网膜素-1 成纤维细胞生长因子-21 

分 类 号：R587.1[医药卫生—内分泌] R587.2[医药卫生—内科学] R392.6[医药卫生—临床医学]