长链非编码RNA在调控癌症放疗敏感性中的研究进展  

Research progress on the role of long non-coding RNA in regulating cancer radiosensitivity

作　　者：朱光浩 朱敏辉 郑宏良 ZHU Guanghao;ZHU Minhui;ZHENG Hongliang(Department of Otolaryngology,Head and Neck Surgery,Shanghai Changhai Hospital of the First Affiliated Hospital of Naval Medical University of the Chinese People′s Liberation Army,Shanghai,200433)

机构地区：[1]中国人民解放军海军军医大学第一附属医院上海长海医院耳鼻咽喉头颈外科,上海200433

出　　处：《实用临床医药杂志》2024年第16期142-148,共7页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(81772881)。

摘　　要：长链非编码RNA(lncRNA)对癌症放疗敏感性的调控作用得到越来越多的重视。放疗是癌症最主要的治疗方法之一,然而部分患者会由于放疗抵抗出现疾病进展或复发。研究癌症放疗过程中的放疗敏感性调控机制,寻找新的分子治疗靶点,对于提高癌症放疗效果有着重要意义。lncRNA可以通过调控DNA损伤反应、细胞凋亡、癌症干细胞和上皮-间质转化(EMT)等多种方式,参与癌症对放疗的响应及调控癌症对放疗的敏感性。本研究讨论lncRNA在癌症放疗领域中机制的研究进展,为增强肿瘤对放疗的敏感性发挥重要作用。The regulatory role of long non-coding RNA(lncRNA)in cancer radiosensitivity has obtained increasing attention.Radiotherapy is one of the primary treatment methods for cancer,yet some patients experience disease progression or recurrence due to radioresistance.Exploring the regulatory mechanisms of radiosensitivity during cancer radiotherapy and identifying new molecular therapeutic targets are crucial for enhancing the efficacy of cancer radiotherapy.LncRNA can participate in the response of cancer to radiotherapy and regulate cancer radiosensitivity through various pathways,including modulation of the DNA damage response,apoptosis,cancer stem cells,and epithelial-mesenchymal transition(EMT).This study discussed the research progress on the mechanisms of lncRNA in the field of cancer radiotherapy,highlighting their important roles in enhancing tumor radiosensitivity.

关 键 词：长链非编码RNA 癌症 放疗 DNA修复 上皮-间质转化 放疗敏感性 

分 类 号：R811.5[医药卫生—放射医学] R730.5[医药卫生—临床医学] R456