急性病毒性肝炎患者血脂、血糖、蛋白、尿酸变化特点及其与预后的关联  

Changes of blood lipid,blood glucose,protein and uric acid in patients with acute viral hepatitis and their correlation with prognosis

作　　者：唐诗 薛传优 叶兴 张鸿举 戴瑞 Tang Shi;Xue Chuanyou;Ye Xing;Zhang Hongju;Dai Rui(Department of Cardiology,the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属徐州市立医院(徐州市第一人民医院)心内科,江苏省221000

出　　处：《中华消化病与影像杂志（电子版）》2024年第5期396-399,共4页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：国家自然科学基金(81900216);江苏大学医教协同创新基金项目(JDYY2023115)。

摘　　要：目的分析急性病毒性肝炎患者血脂、血糖、蛋白、尿酸变化特点及其与预后的关联。方法纳入徐州医科大学附属徐州市立医院2020年1月至2023年1月收治的100例急性病毒性肝炎患者为试验组,选取同期60例健康体检者为对照组,比较试验组与对照组入院时血脂、血糖、蛋白、尿酸、凝血酶原活动度(PTA)差异。试验组治疗8周后,根据预后,将其分为预后良好组、预后不良组,比较2组患者上述指标差异,总结上述指标与患者肝功能及预后的关联。结果试验组谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL);甘油三酯(TG)、空腹血糖(FPG);总蛋白(TP)、尿酸均高于对照组,总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、前白蛋白(PA)、白蛋白(ALB)均低于对照组(P<0.05)。治疗后试验组100例患者中,71例达到治愈标准,21例预后不良。预后良好组ALT、AST、TBIL和TG、FPG、TP、尿酸均低于对照组,TC、HDL-C、LDL-C、ALB、PA、PTA高于对照组(P<0.05)。结论部分急性病毒性肝炎患者预后不理想,与入院时血脂、血糖、蛋白、尿酸水平显著异常有关,且上述指标异常的加剧往往伴随着肝功能显著损伤。Objective To analyze the changes of blood lipid,blood glucose,protein and uric acid in patients with acute viral hepatitis and their correlation with prognosis.Methods A total of 100 patients with acute viral hepatitis admitted to the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University from January 2020 to January 2023 were included in the experimental group,and 60 healthy people in the same period were selected and included in the control group.The differences of blood lipid,blood glucose,protein,uric acid and prothrombin activity(PTA)between the experimental group and the control group were compared.According to the prognosis of the experimental group after 8 weeks of treatment,the patients were divided into good prognosis group and poor prognosis group respectively.The differences of the above indexes between the two groups were compared,and the correlation between the above indexes and the liver function and prognosis of the patients was summarized.Results Alanine aminotransferase(ALT),glutamic oxaloacetic transaminase(AST),total bilirubin(TBIL),triglyceride(TG),fasting blood-glucose(FPG),total protein(TP)and uric acid in the experimental group were higher than those in the control group,while total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),prealbumin(PA)and albumin(ALB)were lower than those in the control group(P<0.05).Among 100 patients in the experimental group,71 cases reached the cure standard,and 21 cases had poor prognosis.ALT,AST,TBIL,TG,FPG,TP and uric acid in the good prognosis group were lower than those in the control group,while TC,HDL-C,LDL-C,ALB,PA and PTA were higher than those in the control group(P<0.05).Conclusion The prognosis of some patients with acute viral hepatitis is not ideal,which is related to the remarkable abnormality of blood lipid,blood glucose,protein and uric acid at admission,and the aggravation of the above indexes is often accompanied by the remarkable damage of liver function.

关 键 词：急性病毒性肝炎 血脂 尿酸 预后 

分 类 号：R512.6[医药卫生—内科学]