内脏疾病背根神经节交感-感觉偶联参与穴位敏化并放大针刺效应  

Sympathetic-sensory coupling in the dorsal root ganglion is involved in acupoint sensitization and amplifies acupuncture effect in visceral diseases

作　　者：李霞[1] 吕涛 奚晗清 崔翔[1] 刘坤[1] 高昕妍[1] LI Xia;LV Tao;XI Han-qing;CUI Xiang;LIU Kun;GAO Xin-yan(Department of Physiology,Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Science,Beijing 100700,China)

机构地区：[1]中国中医科学院针灸研究所机能研究室,北京100700

出　　处：《中国疼痛医学杂志》2024年第9期645-652,共8页Chinese Journal of Pain Medicine

基　　金：国家重点研发计划(2022YFC3500702);国家自然科学基金面上项目(82174518);国家自然科学基金重点项目(82330127)。

摘　　要：最初,在神经病理痛模型中观察到背根神经节(dorsal root ganglion, DRG)交感神经末梢异常芽生的现象。芽生的交感末梢围绕在DRG神经元周围,形成“篮状结构”,即交感-感觉偶联,可以激活感觉神经元,导致疼痛的发生。近年来,学者注意到内脏病变(如心肌缺血)情况下,DRG及相应交感节神经间亦发生交感-感觉偶联,伴随心交感神经功能亢进。本团队既往的研究发现内脏疾病会引起体表痛觉过敏或牵涉痛,参与穴位敏化。交感神经系统通过异常交感功能或者通过影响传入神经异常活动参与上述的病理性变化。而针刺这些敏化穴位放大了穴位本身的生物学效应。本文将阐述交感-感觉偶联与穴位敏化之间的联系以及针刺是否可以通过交感-感觉偶联对内脏疾病产生调控作用。Initially,in a neuropathic pain model,the abnormal sprouting of sympathetic nerve endings in the dorsal root ganglion(DRG)was observed.The sprouted sympathetic nerve endings surround DRG neurons,forming a"basket-like structure",known as sympathetic-sensory coupling,which can activate sensory neurons and lead to the occurrence of pain.Recently,it has been noted that visceral pathologies such as myocardial ischemia give rise to sympathetic-sensory coupling between the DRG and corresponding sympathetic ganglion,often leading to cardiac sympathetic hyperfunction.Our prior research has demonstrated that visceral diseases can cause hyperalgesia or referred pain on the body surface and participate in acupoint sensitization.The sympathetic nervous system plays a pivotal role in these pathological processes,either by developing aberrant sympathetic function or by influencing afferent nerve activity.Moreover,acupuncture at sensitized points enhances the biological effects of these acupoints.The present article aims to explore the intricacies of sympathetic-sensory coupling and acupoint sensitization,and whether acupuncture can regulate visceral diseases via this coupling mechanism.

关 键 词：交感-感觉偶联 针刺 穴位敏化 自主神经 

分 类 号：R245[医药卫生—针灸推拿学]