GABA能神经传递在焦虑症中的作用及相关动物模型的研究进展  

Research Progress on the Role of GABAergic Neurotransmission in Anxiety Disorder and Related Animal Models

作　　者：鲍晓虹 叶田园 程肖蕊 BAO Xiaohong;YE Tianyuan;CHENG Xiaorui(Chinese Medicine Innovation Research Institute,Shandong University of Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学中医药创新研究院,济南250355

出　　处：《中国现代应用药学》2024年第16期2288-2297,共10页Chinese Journal of Modern Applied Pharmacy

基　　金：中央引导地方科技发展专项资金项目(YDZX2023003);西藏自治区科技计划重点研发计划(XZ202201ZY0026G);山东中医药大学研究训练计划项目(S202210441014)。

摘　　要：焦虑症往往伴随着神经递质浓度的异常变化,GABA作为主要的抑制性神经递质,在焦虑症发病机制中发挥重要作用。目前治疗焦虑症的药物主要靶点涉及GABA受体、谷氨酸脱羧酶和GABA转运体。本文系统综述GABA能神经传递在焦虑症发病机制中的作用,并介绍基于GABA能神经传递的焦虑症动物模型的最新研究进展,为进一步深入揭示焦虑症发病机制和新药研发提供借鉴。Anxiety disorders are often accompanied by abnormal changes of the neurotransmitters concentration.GABA,the main inhibitory neurotransmitter,plays an important role in the pathogenesis of anxiety disorders.Main targets of drugs for the treatment of anxiety disorders involve GABA receptors,glutamate decarboxylase and GABA transporters.In addition,the latest research progress of animal models of anxiety based on GABAergic neurotransmission is introduced,which provides a reference for further revealing the pathogenesis of anxiety and the development of new medicine.

关 键 词：焦虑症 GABA能神经传递 GABA受体 GABA转运体 谷氨酸脱羧酶 

分 类 号：R965.1[医药卫生—药理学]