米非司酮分次服用方案用于早孕药物流产患者对治疗效果、起效时间及完全流产率的影响  

The Effect of Mifepristone Fractional Administration on Treatment Efficacy,Onset Time,and Complete Abortion Rate in Patients with Early Pregnancy Induced Abortion

作　　者：包翠禧 BAO Cuixi(Department of Obstetrics and Gynecology,Gutian County Maternal and Child Health Hospital,Ningde 352200,China)

机构地区：[1]古田县妇幼保健院妇产科,宁德352200

出　　处：《中国医药指南》2024年第26期114-116,共3页Guide of China Medicine

摘　　要：目的探讨米非司酮分次服用方案用于早孕药物流产患者对治疗效果、起效时间及完全流产率的影响。方法以2022年2月到2023年2月我院收治的90例早孕药物流产患者为研究对象,随机数字表法分为两组各45例。试验组采用米非司酮分次服药联合米索前列醇,对照组采用米非司酮顿次服药联合米索前列醇。记录孕囊排出时间,超声复查宫内有无妊娠残留物,统计完全流产率。观察两组阴道流血天数与转经时间。统计两组用药相关不良反应发生率。结果试验组完全流产率高于对照组(P<0.05)。试验组用药后孕囊排出时间早于对照组,阴道流血天数短于对照组,不良反应率低于对照组(均P<0.05)。两组转经时间比较,差异无统计学意义(P>0.05)。结论米非司酮分次服用方案在早孕药物流产患者中的应用可以加速孕囊组织排出,提高完全流产率,同时缩短流产后阴道流血时间,效果优于米非司酮顿服用药且不良反应更少。Objective To explore the effects of a phased administration of mifepristone on the treatment efficacy,onset time,and complete abortion rate in patients with early pregnancy induced abortion.Methods Ninety cases of early pregnancy medication abortion patients admitted to our hospital from February 2022 to February 2023 were used as the study subjects,and they were divided into two groups of 45 cases each by random number table method.The experimental group used mifepristone in divided doses combined with misoprostol,and the control group used used mifepristone in one dose combined with misoprostol.Record the time of expulsion of the gestational sac,ultrasonic review of intrauterine pregnancy residue,and statistics of complete abortion rate.Observe the number of days of vaginal bleeding and transit time in the two groups.Statistics on the incidence of drug-related adverse reactions in the two groups.Results The rate of complete abortion in the test groupwas higher than that in the control group(P<0.05).The time of expulsion of the gestational sac after medication in the experimental group was earlier than that in the control group,the number of days of vaginal bleeding was shorter than that in the control group,and the rate of adverse reactions was lower than that in the control group(P<0.05).There was no statistically significant difference in transit time between the two groups(P>0.05).Conclusions The application of mifepristone fractional administration in patients with early pregnancy induced abortion can accelerate the expulsion of gestational sac tissue,improve the complete abortion rate,and shorten the time of vaginal bleeding after abortion.The effect is better than taking mifepristone and the adverse reactions are better.

关 键 词：早孕 药物流产 米非司酮 分次服用方案 起效时间 完全流产率 

分 类 号：R714.21[医药卫生—妇产科学]