早期多频次高压氧治疗急性脑梗死患者的效果  

Effects of early multi-frequency hyperbaric oxygen therapy on patients with acute cerebral infarction

作　　者：赵雨欣 ZHAO Yuxin(Department of Neurology of Shangqiu First People’s Hospital,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市第一人民医院神经内科,河南商丘476000

出　　处：《中国民康医学》2024年第18期20-22,30,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察早期多频次高压氧治疗急性脑梗死患者的效果。方法:回顾性分析2022年7月至2023年7月该院收治的90例急性脑梗死患者的临床资料,依据高压氧治疗频次不同将其分为对照组和研究组各45例。对照组应用低频次高压氧治疗,研究组应用多频次高压氧治疗,比较两组疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、日常生活能力[改良Barthel指数(MBI)]评分、神经功能指标[神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100β)、胶质纤维酸性蛋白(GFAP)]水平、炎性因子[C反应蛋白(CRP)、基质金属蛋白酶-9(MMP-9)]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.56%(43/45),高于对照组的82.22%(37/45),差异有统计学意义(P<0.05);治疗后,研究组NIHSS评分低于对照组,MBI评分高于对照组,差异均有统计学意义(P<0.05);治疗后,研究组S100β、NSE、GFAP、CRP、MMP-9水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:早期多频次高压氧治疗急性脑梗死患者可提高治疗总有效率和日常生活能力评分,降低NIHSS评分、神经功能指标水平和炎性因子水平,效果优于低频次高压氧治疗。Objective:To observe effects of early multi-frequency hyperbaric oxygen therapy on patients with acute cerebral infarction.Methods:The clinical data of 90 patients with acute cerebral infarction admitted to this hospital from July 2022 to July 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,45 cases in each group.The control group was treated with low-frequency hyperbaric oxygen therapy,while the study group was treated with multi-frequency hyperbaric oxygen therapy.The therapeutic effects,the neurological deficit[National Institutes of Health stroke scale(NIHSS)]score,the daily living ability[modified Barthel index(MBI)]score,the neurological function index[neuron-specific enolase(NSE),central nervous specific protein(S100β),glial fibrillary acidic protein(GFAP)]levels,the inflammatory factor[C-reactive protein(CRP),matrix metalloproteinase-9(MMP-9)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.56%(43/45),which was higher than 82.22%(37/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score of the study group was lower than that of the control group,the MBI score was higher than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of S100β,NSE,GFAP,CRP and MMP-9 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Early multi-frequency hyperbaric oxygen therapy for the patients with acute cerebral infarction can improve the total effective rate of treatment and the daily living ability scores,and reduce the NIHSS scores,the neurological function index levels and the inflammatory factor levels.M

关 键 词：急性脑梗死 早期 多频次高压氧 神经功能缺损 日常生活能力 炎性因子 不良反应 

分 类 号：R459.6[医药卫生—治疗学]