双歧杆菌四联活菌联合美洛西林钠治疗感染性腹泻患儿的效果  

Effects of Viable bifidobacterium quadruple combined with Mezlocillin sodium in treatment of children with infectious diarrhea

作　　者：张萌 ZHANG Meng(Department of Pediatrics of Pingqiao District Maternal and Child Health Hospital of Xinyang City,Xinyang 464000 Henan,China)

机构地区：[1]信阳市平桥区妇幼保健院儿科,河南信阳464000

出　　处：《中国民康医学》2024年第18期44-47,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察双歧杆菌四联活菌联合美洛西林钠治疗感染性腹泻患儿的效果。方法:回顾性分析2022年1月至2023年2月该院收治的98例感染性腹泻患儿的临床资料,按照治疗方法不同将其分为对照组和观察组各49例。对照组采用美洛西林钠治疗,观察组在对照组基础上联合双歧杆菌四联活菌治疗,比较两组临床疗效、症状改善时间,治疗前后营养指标[视黄醇结合蛋白(RBP)、游离脂肪酸(FFA)]水平、肠黏膜屏障指标[D-乳酸、二胺氧化酶(DAO)]水平、肠道菌群数量、炎性指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平,以及不良反应发生率。结果:观察组治疗总有效率为93.88%(46/49),高于对照组的77.55%(38/49),差异有统计学意义(P<0.05);观察组发热、腹泻、呕吐、腹痛等症状改善时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组RBP、FFA水平均高于对照组,D-乳酸、DAO水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组肠杆菌、肠球菌菌群数量均少于对照组,乳酸杆菌、双歧杆菌菌群数量均多于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清IL-6、TNF-α、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双歧杆菌四联活菌联合美洛西林钠治疗感染性腹泻患儿可提高治疗总有效率和营养指标水平,缩短症状改善时间,改善肠道菌群数量,降低肠黏膜屏障指标和炎性指标水平,效果优于单纯美洛西林钠治疗。Objective:To observe effects of Viable bifidobacterium quadruple combined with Mezlocillin sodium in treatment of children with infectious diarrhea.Methods:The clinical data of 98 children with infectious diarrhea admitted to this hospital from January 2022 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,49 cases in each group.The control group was treated with Mezlocillin sodium,while the observation group was treated with Viable bifidobacterium quadruple on the basis of that of the control group.The clinical efficacy,the symptom improvement time,the nutritional indexes[retinol binding protein(RBP),free fatty acid(FFA)]levels,the intestinal mucosal barrier indexes[D-lactic acid,diamine oxidase(DAO)]levels,the intestinal flora number,the inflammatory factor[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.88%(46/49),which was higher than 77.55%(38/49)of the control group,and the difference was statistically significant(P<0.05).The improvement time of fever,diarrhea,vomiting and abdominal pain in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of RBP and FFA in the observation group were higher than those in the control group,the levels of D-lactic acid and DAO were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the number of Enterobacter and Enterococcus in the observation group was less than that in the control group,the number of Lactobacilli and Bifidobacteria was more than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum IL-6,TNF-αand hs-CRP in

关 键 词：儿童 感染性腹泻 双歧杆菌四联活菌 美洛西林钠 营养 肠道菌群 炎性因子 

分 类 号：R725.7[医药卫生—儿科]