C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury  

作　　者：Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi 

机构地区：[1]School of Medicine,Guangxi University,Nanning,Guangxi Zhuang Autonomous Region,China [2]Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin,China [3]Characteristic Medical Center of People’s Armed Police Forces,Tianjin,China [4]Fujian Maternity and Child Health Hospital,Fuzhou,Fujian Province,China

出　　处：《Neural Regeneration Research》2025年第8期2231-2244,共14页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Key Program),No.11932013;the National Natural Science Foundation of China(General Program),No.82272255;Armed Police Force High-Level Science and Technology Personnel Project;The Armed Police Force Focuses on Supporting Scientific and Technological Innovation Teams;Key Project of Tianjin Science and Technology Plan,No.20JCZDJC00570(all to XC)。

摘　　要：Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关 键 词：apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method 

分 类 号：R651.2[医药卫生—外科学]