From Perspective of Hippocampal Plasticity:Function of Antidepressant Chinese Medicine Xiaoyaosan  

作　　者：ZHANG Wu-jing GUO Ze-xuan WANG Yi-di FANG Shao-yi WAN Chun-miao YU Xiao-long GUO Xiao-fang CHEN Yue-yue ZHOU Xuan HUANG Jun-qing LI Xiao-juan CHEN Jia-xu FAN Li-li 

机构地区：[1]Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Jinan University,Guangzhou,510632,China

出　　处：《Chinese Journal of Integrative Medicine》2024年第8期747-758,共12页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.82304746);Jinan University Innovation and Entrepreneurship Training Program for Undergraduate(No.CX21255 and CX22481)。

摘　　要：The hippocampus is one of the most commonly studied brain regions in the context of depression.The volume of the hippocampus is significantly reduced in patients with depression,which severely disrupts hippocampal neuroplasticity.However,antidepressant therapies that target hippocampal neuroplasticity have not been identified as yet.Chinese medicine(CM)can slow the progression of depression,potentially by modulating hippocampal neuroplasticity.Xiaoyaosan(XYS)is a CM formula that has been clinically used for the treatment of depression.It is known to protect Gan(Liver)and Pi(Spleen)function,and may exert its antidepressant effects by regulating hippocampal neuroplasticity.In this review,we have summarized the association between depression and aberrant hippocampal neuroplasticity.Furthermore,we have discussed the researches published in the last 30 years on the effects of XYS on hippocampal neuroplasticity in order to elucidate the possible mechanisms underlying its therapeutic action against depression.The results of this review can aid future research on XYS for the treatment of depression.

关 键 词：DEPRESSION hippocampal neuroplasticity Xiaoyaosan Chinese medicine 

分 类 号：R285[医药卫生—中药学]