GnRH-a联合腹腔镜手术对子宫腺肌症患者临床相关指标、血清CA125水平及卵巢功能的影响  

Effects of GnRH-a combined with laparoscopic surgery on clinical related indexes,serum CA125 level and ovarian function in patients with adenomyosis

作　　者：王雪利 苟兰英 WANG Xueli;GOU Lanying(Gynaecology and Obstetrics Department,Meixian Maternal and Child Health Care Hospital,Baoji 722300;Gynaecology and Obstetrics Department,Taibai County Hospital,Baoji 721600,China)

机构地区：[1]眉县妇幼保健院妇产科,陕西宝鸡722300 [2]太白县医院妇产科,陕西宝鸡721600

出　　处：《临床医学研究与实践》2024年第26期94-97,共4页Clinical Research and Practice

摘　　要：目的探讨促性腺激素释放激素激动剂(GnRH-a)联合腹腔镜手术对子宫腺肌症患者临床相关指标、血清糖类抗原125(CA125)水平及卵巢功能的影响。方法选取2020年1月至2022年2月收治的80例子宫腺肌症患者为研究对象,按照治疗方案的不同将其分为对照组(40例,腹腔镜手术)和观察组(40例,GnRH-a联合腹腔镜手术)。比较两组的治疗效果。结果术后3个月,两组的视觉模拟量表(VAS)评分、经期、经量均明显改善,且观察组优于对照组(P<0.05)。术后3个月,两组的子宫体积减小,CA125水平降低,且观察组优于对照组(P<0.05)。术后3个月,两组的促卵泡激素(FSH)、黄体生成素(LH)及雌二醇(E2)水平均明显降低,且观察组低于对照组(P<0.05)。观察组的不良反应总发生率明显低于对照组(P<0.05)。术后1年,观察组的复发率明显低于对照组(P<0.05)。结论GnRH-a联合腹腔镜手术可改善子宫腺肌症患者的临床症状、体征及卵巢功能,调节CA125水平,降低不良反应发生率及复发率,值得临床应用。Objective To explore the effects of gonadotropin-releasing hormone agonist(GnRH-a)combined with laparoscopic surgery on clinical related indexes,serum carbohydrate antigen 125(CA125)level and ovarian function in patients with adenomyosis.Methods A total of 80 patients with adenomyosis admitted from January 2020 to February 2022 were selected as the research objects.According to the different treatment options,the patients were divided into control group(40 cases,laparoscopic surgery)and observation group(40 cases,GnRH-a combined with laparoscopic surgery).The therapeutic effects of the two groups were compared.Results At 3 months after operation,the Visual Analogue Scale(VAS)score,menstrual period and menstrual volume of the two groups significantly improved,and those in the observation group were better than the control group(P<0.05).At 3 months after operation,the uterine volume and CA125 level of the two groups decreased,and those in the observation group were better than the control group(P<0.05).At 3 months after operation,the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).One year after operation,the recurrence rate of the observation group was significantly lower than that in the control group(P<0.05).Conclusion GnRH-a combined with laparoscopic surgery can improve the clinical symptoms,signs and ovarian function of patients with adenomyosis,regulate the level of CA125,and reduce the incidence of adverse reactions and recurrence rate,which is worthy of clinical application.

关 键 词：促性腺激素释放激素激动剂 腹腔镜手术 子宫腺肌症 糖类抗原CA125 卵巢功能 

分 类 号：R711.71[医药卫生—妇产科学]