血清白脂素与心房颤动的相关性研究  

Correlation of serum asprosin with atrial fibrillation

作　　者：杨浩 禹雪 姚涵 迟润泽 单晓丽 李宾公 YANG Hao;YU Xue;YAO Han;CHI Runze;SHAN Xiaoli;LI Bingong(School of Clinical Medicine,Shandong Second Medical University,Weifang,Shandong,261053;the Second Department of Cardiology,Qingdao Municipal Hospital of Shandong Province,Qingdao,Shandong,266000;Zhengzhou People′s Hospital,Zhengzhou,Henan,450000;Qingdao University,Qingdao,Shandong,266000)

机构地区：[1]山东第二医科大学临床医学院,山东潍坊261053 [2]山东省青岛市市立医院心内二科,山东青岛266000 [3]郑州人民医院,河南郑州450000 [4]青岛大学,山东青岛266000

出　　处：《实用临床医药杂志》2024年第15期36-42,共7页Journal of Clinical Medicine in Practice

基　　金：山东省自然科学基金项目(ZR202211230362)。

摘　　要：目的探讨血清白脂素水平与心房颤动的相关性。方法选取2021年10月—2023年10月在青岛市市立医院心内科住院治疗的心房颤动患者85例为房颤组,同时选取同期住院的正常窦性心律患者86例为非房颤组。收集并比较患者的临床资料和血清白脂素水平。采用Logistic回归分析,根据潜在混杂因素建立线性逐步回归模型,探讨心房颤动的独立危险因素。采用受试者工作特征(ROC)曲线评估血清白脂素对心房颤动的诊断价值。结果房颤组血清白脂素水平高于非房颤组,差异有统计学意义(P<0.001)。线性逐步回归模型显示,高水平白脂素是心房颤动发生的独立危险因素(OR=1.020,95%CI:1.005~1.036,P=0.01)。受试者工作特征(ROC)曲线显示,血清白脂素预测心房颤动发生的曲线下面积为0.745(95%CI:0.670~0.819)。结论血清白脂素水平升高是心房颤动的独立危险因素,且血清白脂素水平对心房颤动具有良好的诊断价值。Objective To investigate the correlation between serum asprosin level and atrial fibrillation.Methods A total of 85 hospitalized patients with atrial fibrillation in the Department of Cardiology of Qingdao Municipal Hospital from October 2021 to October 2023 were selected as atrial fibrillation group,and 86 hospitalized patients with normal sinus rhythm in the same period were selected as non-atrial fibrillation group.Clinical materials and serum asprosin level of patients were collected and compared.Logistic regression analysis was performed to establish a linear stepwise regression model based on potential confounding factors for exploration in the independent risk factors for atrial fibrillation.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of asprosin for atrial fibrillation.Results Serum asprosin level in the atrial fibrillation group,was significantly higher than that in the non-atrial fibrillation group(P<0.001).The linear stepwise regression model showed that asprosin was an independent risk factor for atrial fibrillation(OR=1.020,95%CI,1.005 to 1.036,P=0.01).The ROC curve showed that the area under the curve of serum asprosin in predicting atrial fibrillation was 0.745(95%CI,0.670 to 0.819).Conclusions Serum asprosin level is significantly elevated in patients with atrial fibrillation,and asprosin is an independent risk factor for atrial fibrillation.Serum asprosin level has good diagnostic value for atrial fibrillation.

关 键 词：白脂素 心房颤动 脂肪因子 炎症反应 左心房内径 

分 类 号：R541.7[医药卫生—心血管疾病] R446.11[医药卫生—内科学] R319[医药卫生—临床医学]