犬尿氨酸通路与继发性早泄的关系  

The kynurenine pathway and acquired premature ejaculation

作　　者：曹志 朱天乐 杨鹏[1] 马愉快 高攀[1] 张贤生[1] Cao Zhi;Zhu Tianle;Yang Peng;Ma Yukuai;Gao Pan;Zhang Xiansheng(Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)

机构地区：[1]安徽医科大学第一附属医院泌尿外科,安徽合肥230022

出　　处：《中国男科学杂志》2024年第4期102-106,111,共6页Chinese Journal of Andrology

基　　金：国家自然科学基金面上项目(82371635)。

摘　　要：早泄是一种常见的男性性功能障碍,它严重影响着男性的生活质量以及伴侣关系,可能会造成严重的个人后果,如痛苦、焦虑、紧张等。继发性早泄患者在早泄患者中的占比不低,且更有可能寻求或计划寻求治疗。现有研究表明,5-羟色胺的合成与早泄的发生有重要关系。而作为色氨酸代谢途径之一的犬尿氨酸途径可能也与早泄的发生有关,而目前对于这条通路与早泄之间关系的研究很少,本文主要就犬尿氨酸通路与继发性早泄的关系进行综述。Premature ejaculation is a common male sexual dysfunction.It seriously affects the life quality of patient and the relationship with his spouse,and in the long run,it may lead to serious personal consequences such as distress,anxiety,and stress.The proportion of patients with acquired premature ejaculation is relatively high among premature ejaculation patients,and they are more willing to seek or plan to seek treatment.Existing researches have demonstrated that 5-hydroxytryptophan synthesis is important in the development of premature ejaculation.The kynurenine pathway,which is one of the tryptophan metabolic pathways,may be associated with the development of premature ejaculation.Currently,the relationship between this pathway and premature ejaculation remains largely uncharacterized.This article summarizes and reviews the relationship between the kynurenine pathway and acquired premature ejaculation.

关 键 词：早泄 吲哚胺-吡咯2 3-双加氧酶 犬尿烯酸 喹啉酸 犬尿氨酸 

分 类 号：R698.9[医药卫生—泌尿科学] R349.1[医药卫生—外科学]