新生儿溶血发生低血糖的危险因素调查及用药策略浅析  

Investigation of Risk Factors for Hypoglycemia in Neonatal Hemolysis and Analysis of Medication Strategies

作　　者：王晓磊 王晨 郭俊娜 时捷 WANG Xiaolei;WANG Chen;GUO Junna;SHI Jie(Department of Blood Transfusion,Xinxiang Maternal and Child Health Hospital,Xinxiang 453000,Henan,China;Department of Laboratory Medicine,the Sixth People’s Hospital of Luohe,Luohe 462000,Henan,China;Department of Clinical Laboratory,Qiaoguang Hospital,Zhengzhou 450000,Henan,China;Department of Pain,Xinxiang Maternal and Child Health Hospital,Xinxiang 453000,Henan,China)

机构地区：[1]新乡市妇幼保健院输血科,河南新乡453000 [2]漯河市第六人民医院检验科,河南漯河462000 [3]郑州市侨光医院检验科,河南郑州450000 [4]新乡市妇幼保健院疼痛科,河南新乡453000

出　　处：《中国药物滥用防治杂志》2024年第8期1428-1431,1436,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20230876)。

摘　　要：目的:探究新生儿溶血发生低血糖的危险因素及用药策略。方法:选取本院2022年2月—2024年2月本院接诊的159例新生儿溶血患儿作为研究对象,并根据患儿是否合并低血糖分为低血糖组(n=38)和正常血糖组(n=121)。收集新生儿一般资料和母亲相关信息。单因素分析低血糖组和正常血糖组患儿/母体临床资料差异;Logistic分析新生儿溶血发生低血糖的危险因素。结果:单因素结果显示,低血糖组出生体质量<2500 g、窒息、低氧血症、低体温和胎龄<37周患儿占比高于正常血糖组,患儿母体妊娠糖尿病占比高于正常血糖组(P<0.05);Logistic结果显示,出生体质量<2500g、窒息、低氧血症、低体温、胎龄<37周和母体妊娠糖尿病均是新生儿溶血低血糖发生的危险因素(P<0.05)。结论:新生儿溶血发生低血糖的危险因素包括出生体质量<2500 g、窒息、低氧血症、低体温、胎龄<37周和母体妊娠糖尿病;临床应早期且持续的血糖监测,以便及时发现血糖异常波动,同时可通过静脉输注葡萄糖溶液并密切关注患儿电解质平衡。Objective:To explore the risk factors and medication strategies of hypoglycemia caused by hemolysis in newborns.Methods:A total of 159 neonatal hemolysis children were admitted to our hospital from February 2022 to February 2024 were selected as the study objects,and they were divided into hypoglycemic group(n=38)and normal blood glucose group(n=121)according to whether the children were complicated with hypoglycemia.General neonatal data and maternal information were collected.The difference of clinical data between hypoglycemia group and normal glycemia group was analyzed by single factor.The risk factors of hypoglycemia in neonatal hemolysis were analyzed by Logistic analysis.Results:Single factor results showed that the proportion of children with birth weight<2500 g,asphyxia,hypoxemia,hypothermia and gestational age<37 weeks in hypoglycemia group was higher than that in normal blood glucose group,and the proportion of maternal gestational diabetes mellitus was higher than that in normal blood glucose group(P<0.05).Logistic results showed that birth weight<2500g,asphyxia,hypoxemia,hypothermia,gestational age<37 weeks and maternal gestational diabetes mellitus were all risk factors for neonatal hemolytic hypoglycemia(P<0.05).Conclusion:The risk factors of neonatal hemolysis hypoglycemia include birth weight<2500g,asphyxia,hypoxemia,hypothermia,gestational age<37 weeks and maternal gestational diabetes mellitus.We should clinically monitor the blood glucose of hemolytic newborns early and continuously to detect abnormal blood glucose fluctuations in time.Meanwhile,we can give glucose solution intravenously and pay close attention to the electrolyte balance of children.

关 键 词：新生儿溶血 低血糖 危险因素 用药策略 

分 类 号：R722.1[医药卫生—儿科] R969[医药卫生—临床医学]