IPP预测α-受体阻滞剂治疗良性前列腺增生效果的价值  

Value of IPP in Predicting the Effect ofα-blocker in the Treatment of Benign Prostatic Hyperplasia

作　　者：杨红 郝建伟[2] YANG Hong;HAO Jianwei(Department of Urology,Xincai County People’s Hospital,Xincai 463500,Henan,China;The Second Ward of Urology Department,Henan Provincial People’s Hospital,Henan 450000,Zhengzhou,China)

机构地区：[1]新蔡县人民医院泌尿外科,河南新蔡463500 [2]河南省人民医院泌尿二病区,河南郑州450000

出　　处：《中国药物滥用防治杂志》2024年第8期1440-1444,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190603)。

摘　　要：目的:探讨膀胱内前列腺突出程度(IPP)预测α-受体阻滞剂治疗良性前列腺增生(BPH)效果的价值分析方法。方法:回顾性分析选取2021年12月—2023年12月我院收治的BPH患者85例,所有患者均接受α-受体阻滞剂治疗,根据患者治疗效果将其分成有效组和无效组,对比两组临床资料和疾病相关特征,选择Logistic回归分析有差异项目,得出影响患者临床疗效的因素。并绘制ROC曲线分析IPP对α-受体阻滞剂治疗BPH效果预测价值。结果:共纳入85例BPH患者,按临床疗效将患者分成有效组58例(68.24%)和无效组27例(27.78%);无效组IPP、PVR、PSA水平和有效组比较,差异有统计学意义(P<0.05);经Logistic回归方程分析显示,IPP、PVR、PSA水平均是影响α-受体阻滞剂治疗BPH效果的独立因素;通过绘制ROC图发现,IPP、PVR、PSA水平AUC值分别为0.816、0.638、0.721,其灵敏度和特异度较高,其中IPP的AUC值高于PVR、PSA(P<0.05),在预测α-受体阻滞剂治疗BPH效果中存在较高价值。结论:IPP、PVR、PSA均是影响患者治疗效果的因素,其中IPP的AUC值较高,可用于α-受体阻滞剂治疗BPH效果的预测。Objective:To investigate the value of intravesical prostatic protrusion(IPP)in predicting the efficacy ofα-blocker in the treatment of benign prostatic hyperplasia(BPH).Methods:A retrospective analysis of 85 patients with BPH admitted to our hospital from December 2021 to December 2023 was selected.All patients were treated withα-receptor blockers.According to the therapeutic effect of the patients,they were divided into effective group and ineffective group.The clinical data and disease-related characteristics of the two groups were compared.Logistic regression analysis was used to analyze the difference items and obtain the factors affecting the clinical efficacy of the patients.The ROC curve was drawn to analyze the predictive value of IPP in the treatment of BPH withα-blockers.Results:A total of 85 patients with BPH were included.According to the clinical efficacy,the patients were divided into effective group(58 patients,68.24%)and ineffective group(27 patients,27.78%).There were significant differences in IPP,PVR and PSA levels between the ineffective group and the effective group(P<0.05).Logistic regression analysis showed that IPP,PVR and PSA levels were independent factors affecting the efficacy ofα-receptor blockers in the treatment of BPH.By drawing the ROC diagram,it was found that the AUC values of IPP,PVR and PSA levels were 0.816,0.638 and 0.721,respectively,with high sensitivity and specificity.The AUC value of IPP was higher than that of PVR and PSA(P<0.05),which had a high value in predicting the effect ofα-receptor blockers in the treatment of BPH.Conclusion:IPP,PVR and PSA are all factors affecting the therapeutic effect of patients.The AUC value of IPP is higher,which can be used to predict the effect ofα-blocker in the treatment of BPH.

关 键 词：Α-受体阻滞剂 良性前列腺增生 排尿障碍 

分 类 号：R697.3[医药卫生—泌尿科学]