Influence of Biomimetic Apatite Coating on the Biobehavior of TiO_(2)Scaffolds  

作　　者：Shima Mahtabian Seyed Mehdi Mirhadi Nahid Hassanzadeh Nemati Melika Sharifi Fariborz Tavangarian 

机构地区：[1]Department of Biomedical Engineering,University of Delaware,Newark,DE,19716,USA [2]Department of Ceramic Engineering,Islamic Azad University(Shahreza Branch),Shahreza,Isfahan,86145-311,Iran [3]Department of Biomedical Engineering,Islamic Azad University(Science and Research Branch),Tehran,Iran [4]Mechanical Engineering Program,School of Science,Engineering and Technology,Pennsylvania State University,Harrisburg,Middletown,PA,17057,USA [5]Department of Materials Science&Engineering,Islamic Azad University(Najaf Abad Branch),Najaf Abad,Isfahan,8514143131,Iran [6]Biomedical Engineering Department,Pennsylvania State University,State College,University Park,Pennsylvania,16802,USA

出　　处：《Journal of Bionic Engineering》2024年第4期1975-1986,共12页仿生工程学报（英文版）

摘　　要：Immersion of scaffolds in Simulated Body Fluid(10SBF)is a standardized method for evaluating their bioactivity,simulating in vivo conditions where apatite deposits can be formed on the surface of scaffold,facilitating bone integration and ensuring their suitability for bone implant purposes,ultimately contributing to long-term implant success.The effect of apatite deposition on bioactivity and cell behavior of TiO_(2)scaffolds was studied.Scaffolds were soaked in 10SBF for different durations to form HAP layer on their surface.The results proved the development of a hydroxyapatite film resembling the mineral composition of bone Extracellular Matrix(ECM)on the TiO_(2)scaffolds.The XRD test findings showed the presence of hydroxyapatite layer similar to bone at the depth of 10 nm.A decrease in the specific surface area(18.913 m^(2)g^(−1)),the total pore volume(0.045172 cm^(3)g^(−1)(at p/p0=0.990)),and the mean pore diameter(9.5537 nm),were observed by BET analysis which confirmed the formation of the apatite layer.It was found that titania scaffolds with HAP coating promoted human osteosarcoma bone cell(MG63)cell attachment and growth.It seems that immersing the scaffolds in 10SBF to form HAP coating before utilizing them for bone tissue engineering applications might be a good strategy to promote bioactivity,cell attachment,and implant fixation.

关 键 词：TITANIA Hierarchical meso/macro porous 10SBF Biomimetic apatite Coating 

分 类 号：Q811[生物学—生物工程] R318[医药卫生—生物医学工程]