Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction?  

作　　者：Ria Margiana Younes Pilehvar Fatkhurrohmah LAmalia Silvia WLestari Supardi Supardi Reny I’tishom 

机构地区：[1]Department of Anatomy,Faculty of Medicine,Universitas Indonesia,Jakarta,Indonesia [2]Master’s Programme Biomedical Sciences,Faculty of Medicine,Universitas Indonesia,Jakarta,Indonesia [3]Andrology Program,Faculty of Medicine,Universitas Airlangga,Surabaya,Indonesia [4]Dr.Soetomo General Academic Hospital,Surabaya,Indonesia [5]Indonesia General Academic Hospital,Depok,Indonesia [6]Ciptomangunkusumo General Academic Hospital,Jakarta,Indonesia [7]Cellular and Molecular Research Center,Cellular and Molecular Medicine Research Institute,Urmia University of Medical Science,Urmia,Iran [8]Dr.Kariadi Hospital,Semarang,Indonesia [9]Department of Medical Biology,Faculty of Medicine,Universitas Indonesia,Jakarta,Indonesia [10]Department of Biomedical Science,Faculty of Medicine,Universitas Airlangga Surabaya,Indonesia

出　　处：《Asian Journal of Urology》2024年第3期391-405,共15页亚洲泌尿外科杂志（英文）

摘　　要：Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MSCs),holds therapeutic promise in regenerative medicine.This review aimed to explore the therapeutic potential of the MSC secretome in regenerative urology,particularly for treating erectile dysfunction(ED),and to provide an overview of preclinical and clinical research on MSCs in ED treatment and subsequently to highlight the rationales,mechanisms,preclinical investigations,and therapeutic potential of the MSC secretome in this context.Methods:The review incorporated an analysis of preclinical and clinical research involving MSCs in the treatment of ED.Subsequently,it delved into the existing knowledge regarding the MSC secretome,exploring its therapeutic potential.The methods included a comprehensive examination of relevant literature to discern the processes underlying the therapeutic efficacy of the MSC secretome.

关 键 词：Erectile dysfunction Mesenchymal stem cell Mesenchymal stem cell secretome Mesenchymal stem cell-derived exosome 

分 类 号：R698[医药卫生—泌尿科学]