Bending short DNAs as transversely isotropic rings in series  

将短DNA简化成串联的横观各向同性环进行弯曲

作　　者：Chenyu Shi Meicheng Yao Bin Chen 石陈玉;姚美成;陈彬(Department of Engineering Mechanics,Zhejiang University,Hangzhou 310027,China;Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province,Hangzhou 310027,China)

机构地区：[1]Department of Engineering Mechanics,Zhejiang University,Hangzhou 310027,China [2]Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province,Hangzhou 310027,China

出　　处：《Acta Mechanica Sinica》2024年第7期206-212,共7页力学学报（英文版）

基　　金：supported by Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ23A020004);the National Natural Science Foundation of China(Grant Nos.12372318 and 11872334).

摘　　要：Despite the significance of the high flexibility exhibited by short DNAs,there remains an incomplete understanding of their anomalous persistence length.In this study,we propose to model each basic unit of gene sequences within short DNAs as a transversely isotropic ring.Our comprehensive model analysis successfully replicates the observed high flexibility of short DNAs and also displays the impact of sequence dependence,aligning with experimental findings.Furthermore,our analysis suggests that the bending behavior of short DNAs can be effectively described by the Timoshenko beam theory with the consideration of shear.尽管短DNA表现出的高柔性具有重要意义,但对其异常持续长度的机理仍未完全弄清楚.在本研究中,我们建议将短DNA中基因序列的每个基本单元建模为一个横观各向同性环.我们的模型分析成功重演了所观测到的短DNA高柔性,并显示了序列依赖性的影响,与实验结果一致.此外,我们的分析表明,短DNA的弯曲行为可以通过考虑剪切的Timoshenko梁理论进行有效描述.

关 键 词：DNA Persistence length Timoshenko beam theory Transversely isotropic BENDING 

分 类 号：O3[理学—力学]