基于TBSS对女性偏头痛脑白质变化的研究  

A study of white matter changes in female migraine patients based on TBSS

作　　者：张亚男[1] 韩芳 刘妮 吴浩然 罗煊之 刘慧林[4] 霍健伟 王朝晖[1] ZHANG Yanan;HAN Fang;LIU Ni;WU Haoran;LUO Xuanzhi;LIU Huilin;HUO Jianwei;WANG Zhaohui(Department of Radiology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Office of Academic Research,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;Acupuncture and Moxibustion Department,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院放射科,北京100010 [2]首都医科大学附属北京中医医院科研处,北京100010 [3]北京中医药大学生命科学学院,北京100029 [4]首都医科大学附属北京中医医院针灸科,北京100010

出　　处：《中国中西医结合影像学杂志》2024年第5期532-537,共6页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：北京市属医院科研培育项目(PZ2021016);北京市医院管理中心培育计划项目(PZ2020013);北京市职工创新工作室创新助推项目。

摘　　要：目的:通过DTI技术检测女性无先兆偏头痛患者偏头痛发作间期的脑白质结构变化,以及其与临床特征之间的关系。方法:招募43例女性偏头痛患者(偏头痛组)和43例匹配的健康志愿者(对照组)。2组均行MRI扫描,其中偏头痛患者在发作间期采集DTI和临床数据。采用基于纤维束示踪的空间统计方法比较2组间脑白质的差异。DTI指标与临床指标行Pearson相关性分析。结果:与对照组相比,偏头痛组的胼胝体膝、体及压部、双侧前辐射冠、双侧上辐射冠、双侧内囊前后肢、左侧上纵束、右侧钩束及右侧扣带的轴向扩散系数均明显降低(均P<0.05)。2组各向异性分数、平均扩散系数和径向扩散系数差异均无统计学意义(均P>0.05)。结论:女性偏头痛患者出现疼痛相关脑白质的轴突损伤,这些发现可能有助于阐明偏头痛的中枢机制。Objective:To detect the white matter changes in female migraine patients during the interictal period using DTI as well as its relationship and clinical characteristics.Methods:Forty-three female migraine patients(migraine group)and forty-three matched healthy volunteers(control group)were recruited.DTI and clinical data were acquired during the headache attacks.A tract-based spatial statistics(TBSS)method was used to compare white matter differences between the two groups.Furthermore,Pearson correlation analysis was used to analyze the relationship between DTI metrics and clinical indicators.Results:Compared with the control group,the migraine group demonstrated significantly decreased axial diffusivity in the genu,body and splenium of corpus callosum,the bilateral superior corona radiata,the bilateral anterior and posterior limb of the internal capsule,the left superior longitudinal fasciculus and right uncinate fasciculus and the right cingulate gyrus(all P<0.05).There were no differences of two groups in fractional anisotropy,mean diffusivity,or radial diffusivity(all P>0.05).Conclusions:Female migraine patients have pain-related white matters axonal damage,which may help elucidate the central mechanisms of migraine.

关 键 词：偏头痛 女性 磁共振成像 脑白质 轴突损伤 

分 类 号：R445.2[医药卫生—影像医学与核医学] R747.2[医药卫生—诊断学]