基于冠状动脉CT血管成像评估高危斑块特征与血清高敏C反应蛋白水平的关系  

Relationship between high-risk plaque characteristics evaluated by coronary CTA and high-sensitivity C-reactive protein levels

作　　者：陈治宇 徐晗 颜欢欢[2] 蒿保利 于德新[1] 杨传彬 CHEN Zhiyu;XU Han;YAN Huanhuan;HAO Baoli;YU Dexin;YANG Chuanbin(Department of Radiology,Qilu Hospital of Shandong University,Jinan 250012,China;Department of Medical Imaging,Jinan Third People’s Hospital,Jinan 250132,China;Department of Radiology,Shandong Public Health Clinical Center,Jinan 250102,China)

机构地区：[1]山东大学齐鲁医院放射科,山东济南250012 [2]山东省济南市第三人民医院影像中心,山东济南250132 [3]山东省公共卫生临床中心放射科,山东济南250102

出　　处：《中国中西医结合影像学杂志》2024年第5期554-558,共5页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:探讨冠状动脉CT血管成像(CCTA)识别的高危斑块特征与血清高敏C反应蛋白(hs-CRP)水平的关系。方法:回顾性分析同时接受血清hs-CRP和CCTA检查的118例冠状动脉粥样硬化性心脏病(冠心病)患者。根据患者的hs-CRP水平,将其分为低水平组(hs-CRP≤3 mg/L)62例和高水平组(hs-CRP>3 mg/L)56例。评估并比较2组CT高危斑块特征在CCTA图像上的出现率,以及临床基线资料和CCTA识别的高危斑块特征。结果:高水平组中有吸烟史患者比例(48.21%)高于低水平组(27.42%)(P=0.020)。低密度斑块和餐巾环征在高水平组中更常见(分别为64.10%vs.38.57%和28.21%vs.14.29%),而点状钙化在低水平组的发生率(27.14%)高于高水平组(14.10%)。多因素logistic回归分析结果显示,吸烟史及低密度斑块是hs-CRP水平升高的独立危险因素。结论:CCTA识别的低密度斑块和餐巾环征在hs-CRP水平较高的患者中更常见,且吸烟史与低密度斑块是血清hs-CRP水平升高的独立危险因素。Objective:To investigate the relationship between high-risk plaque characteristics identified by coronary CTA(CCTA)and serum high-sensitivity C-reactive protein(hs-CRP)levels.Methods:A retrospective analysis was conducted on 118 patients with coronary atherosclerotic heart disease(coronary heart disease,CHD)who simultaneously underwent serum hs-CRP and CCTA examinations.According to the patients’hs-CRP levels,they were divided into a low-level group(62 cases,hs-CRP≤3 mg/L)and a high-level group(56 cases,hs-CRP>3 mg/L).The occurrence rates of CT high-risk plaque characteristics on CCTA images,clinical baseline data and high-risk plaque characteristics identified by CCTA were evaluated and compared between the two groups.Results:The proportion of patients with a smoking history in the high-level group was higher than that in the low-level group(48.21%vs.27.42%)(P=0.020).Low-density plaques and napkin-ring signs were more common in the high-level group(64.10%vs.38.57%,28.21%vs.14.29%),while the occurrence rate of spotty calcification in the low-level group was higher than that in the high-level group(27.14%vs.14.10%).Multivariate logistic regression analysis showed that the smoking history and low-density plaques were independent risk factors for elevated hs-CRP levels.Conclusion:Low-density plaques and napkin-ring sign identified by CCTA are more common in patients with high level of hs-CRP,and the smoking history and low-density plaques are independent risk factors for elevated serum hs-CRP levels.

关 键 词：冠状动脉CT血管成像 高敏C反应蛋白 高危斑块 

分 类 号：R541.4[医药卫生—心血管疾病] R816.2[医药卫生—内科学]