定量CT在探究健康体检人群腹部脂肪分布与高尿酸血症相关性中的应用  

Application of quantitative CT technique to investigate the correlation between abdominal fat distribution and hyperuricemia in healthy population in physical examination

作　　者：和俊雅 孙永兵 戚昕 李中林[1] 周菁 邹智 李昊 周阳 杜亚玮[1,2] 屈敏 窦社伟 刘红明[1] 闫峰山[1] 朱嘉栋[5] 吕雪 李永丽[5] HE Junya;SUN Yongbing;QI Xin;LI Zhonglin;ZHOU Jing;ZOU ZHI;LI Hao;ZHOU Yang;DU Yawei;QU Min;DOU Shewei;LIU Hongming;YAN Fengshan;ZHU Jiadong;LÜXue;LI Yongli(Department of Medical Imaging,Henan Provincial People’s Hospital,Zhengzhou 450003,China;Henan University,Kaifeng 475001,China;Zhengzhou University,Zhengzhou 450001,China;Xinxiang Medical University,Xinxiang 453003,China;Health Management Department of Henan Provincial People’s Hospital,Henan Key Laboratory of Chronic Disease Management,Zhengzhou 450003,China;Fuwai Central China Cardiovascular Hospital,Zhengzhou 451464,China)

机构地区：[1]河南省人民医院医学影像科,河南郑州450003 [2]河南大学,河南开封475001 [3]郑州大学,河南郑州450001 [4]新乡医学院,河南新乡453003 [5]河南省人民医院健康管理学科/河南省慢病健康管理重点实验室,河南郑州450003 [6]阜外华中心血管病医院,河南郑州451464

出　　处：《中国中西医结合影像学杂志》2024年第5期570-575,共6页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(82071884);中原科技创新领军人才计划(244200510016);河南省医学科技计划项目(SBGJ202302011);河南省科技攻关计划项目(242102311018,242102311121,242102310299)。

摘　　要：目的:采用定量CT探讨健康体检人群腹部脂肪分布与高尿酸血症的关系。方法:纳入10887例健康体检者为研究对象。将内脏脂肪面积(VFA)、皮下脂肪面积(SFA)根据QL、QU由小到大均分成4等份,分别为Q_(1)、Q_(2)、Q_(3)、Q_(4)。采用多因素logistic回归分析构建4个模型评估VFA、SFA与高尿酸血症的相关性;并根据完全调整模型,按性别因素进行分层分析。结果:高尿酸血症的总检出率为20.2%(2196/10887),男性检出率明显高于女性(P<0.05)。在完全调整模型中,VFA在Q_(2)~Q_(4)发生高尿酸血症的风险分别是Q_(1)的1.73倍(1.42~2.10)、2.44倍(1.95~3.04)、2.99倍(2.32~3.86),趋势性检验P<0.001;SFA在Q_(2)~Q_(4)发生高尿酸血症的风险分别是Q_(1)的0.95倍(0.82~1.11)、0.99倍(0.85~1.16)、1.17倍(0.97~1.42),趋势性检验P=0.109。不同性别的VFA Q_(2)~Q_(4)发生高尿酸血症风险的趋势性检验均P<0.05;而男性的SFA Q_(2)~Q_(4)发生高尿酸血症风险的趋势性检验P<0.05,女性中趋势性检验P>0.05。结论:健康体检人群中,VFA的增加与高尿酸血症的发生风险呈正相关,VFA可作为高尿酸血症防治的重要监测指标;对于SFA,该关联仅存在男性中。Objective:To explore the relationship between abdominal fat distribution and hyperuricemia in healthy population in physical examination by quantitative CT(QCT)technology.Methods:A total of 10,887 healthy person in physical examination were included as study subjects.Visceral fat area(VFA)and subcutaneous fat area(SFA)were divided into 4 groups according to the interquartile interval(from Q_(1)to Q_(4)).Multivariate logistic regression analysis was used to establish four models to assess the correlation between VFA,SFA and hyperuricemia,according to the fully adjusted model,the analysis was stratified according to gender factors.Results:The overall detection rate of hyperuricemia was 20.2%,the detection rate of male was significantly higher than that of female(P<0.05).In the fully adjusted model,the risk of hyperuricemia in Q_(2),Q_(3),Q_(4)group of VFA was 1.73(1.42~2.10),2.44(1.95~3.04)and 2.99(2.32~3.86)times as compared with Q_(1)group,respectively,trend test P<0.001.The risk of hyperuricemia in Q_(2),Q_(3),Q_(4)group of SFA was 0.95(0.82~1.11),0.99(0.85~1.16)and 1.17(0.97~1.42)times as compared with Q_(1)group,respectively,trend test P=0.109.Trend test P values of the risk of hyperuricemia in VFA Q_(2),Q_(3),Q_(4)group were less than 0.05 in both men and women,while trend test P values of the risk of hyperuricemia in VFA Q_(2),Q_(3),Q_(4)group were less than 0.05 in men,but greater than 0.05 in women.Conclusions:In the healthy population in physical examination,the increase of VFA is positively correlated with the risk of hyperuricemia,and VFA can be used as an important monitoring indicator for the prevention and treatment of hyperuricemia,while the association between SFA hyperuricemia is found only in men.

关 键 词：高尿酸血症 内脏脂肪面积 皮下脂肪面积 体层摄影术 X线计算机 

分 类 号：R589.7[医药卫生—内分泌]