低负荷血流限制训练联合关节腔内注射治疗老年膝骨关节炎的效果  

The Clinical Effect of Low-load Blood Flow Restriction Training Combined with Intra-articular Injection for Elderly Knee Osteoarthritis

作　　者：花洪宁 顾晓东 吴斗[1] Hua Hongning;Gu Xiaodong;Wu Dou(The Third Hospital of Shanxi Medical University(Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital),Taiyuan 030032)

机构地区：[1]山西医科大学第三医院、山西白求恩医院、山西医学科学院、同济山西医院,太原030032

出　　处：《国际老年医学杂志》2024年第5期541-545,共5页International Journal of Geriatrics

基　　金：山西省基础研究计划项目(20210302123488);山西省大健康产业高质量发展科研专项课题(DJKZXKT2023199)。

摘　　要：目的探讨低负荷血流限制训练联合关节腔内注射治疗老年膝骨关节炎的临床疗效。方法方便抽样法选取2023年山西医科大学第三医院收治的126例老年膝骨关节炎患者作为研究对象,按照随机数表法分为两组,各63例。对照组行单纯关节腔注射利多卡因、玻璃酸钠,观察组在对照组的基础上增加低负荷血流限制训练。分别于治疗前、治疗后评估西安大略和曼彻斯特大学骨性关节炎指数(WOMAC)、疗效、生活质量综合评定问卷-74(GQOLI-74)评分、伸膝力矩、膝内收力矩、血清基质金属蛋白酶(MMP)-1、MMP-3水平。结果治疗后观察组WOMAC各维度及总分、MMP-1、MMP-3水平均低于对照组(P<0.05),观察组临床总有效率、GQOLI-74评分的各维度及总分、伸膝力矩、膝内收力矩均高于对照组(P<0.05)。结论低负荷血流限制训练联合关节腔内注射治疗老年膝骨关节炎具有良好的临床疗效,可以显著缓解患者的疼痛,提高关节功能和生活质量,其治疗机制可能与降低MMP-1、MMP-3水平有关。Objective To investigate the clinical effect of low-load blood flow restriction training combined with intra-articular injection for elderly knee osteoarthritis.Methods A total of 126 elderly patients with knee osteoarthritis admitted to the Third Hospital of Shanxi Medical University in 2023 were selected as the study subjects by convenient sampling method,they divided into two groups according to the random number table,63 cases for each group.The control group received simple intra-articular injection,and the observation group was additionally trained with low-load blood flow restriction.Western Ontario and the University of Manchester Osteoarthritis Index(WOMAC),efficacy,generic quality of life inventory 74(GQOLI-74)score,knee extension moment,knee adduction moment,serum matrix metalloproteinase(MMP)-1,and MMP-3 levels were assessed before and after treatment.Results After treatment,the WOMAC dimensions and total score,MMP-1 and MMP-3 levels in the observation group were lower than those in the control group(P<0.05),and the clinical total effective rate,GQOLI-74 score dimensions and total score,knee extension moment and knee adduction moment in the observation group were higher than those in the control group(P<0.05).Conclusion Low-load blood flow restriction training combined with intra-articular injection for elderly knee osteoarthritis has good clinical efficacy,which can significantly relieve pain,improve joint function and quality of life of patients,and its treatment mechanism may be related to lower levels of MMP-1 and MMP-3.

关 键 词：膝骨关节炎 低负荷血流限制训练 关节腔注射 疗效 

分 类 号：R684.3[医药卫生—骨科学]