Quorum Sensing:An Emerging Role for Vibrio Infection and Host Defense  

作　　者：Hao-Nan Lin Xian-Hui Huang Xin-Jun Miao Wei-Lin Hu Yong-Liang Lou Dan-Li Xie 

机构地区：[1]The School of Laboratory Medicine&Life Sciences,Wenzhou Medical University,Wenzhou,China [2]Key Laboratory of Laboratory Medicine,Ministry of Education of China,Wenzhou,China [3]Wenzhou Key Laboratory of Sanitary Microbiology,Wenzhou,China [4]Department of Emergency,Wenzhou Central Hospital,Wenzhou,Zhejiang,China [5]Department of Microbiology,School of Medicine,Zhejiang University,Hangzhou,China [6]Zhuji Institute of Biomedical Research,School of Pharmacy,Wenzhou Medical University,Zhuji,China

出　　处：《Infectious Microbes & Diseases》2024年第2期47-55,共9页感染微生物与疾病（英文）

基　　金：the National Key Research and Development Program(2021YFC2300300);the Natural Science Foundation of Zhejiang Province(LY22H190002);the National Natural Science Foundation of China(81971951);the Industry School Cooperation Collaborative Education Project of Ministry of Education of China(220604408244731).

摘　　要：Quorum sensing(QS)is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting,sensing and responding to signaling molecules called autoinducers(AIs).In Vibrio species,QS plays a crucial role in modulating different biological characteristics.QS can influence the formation of biofilms,which are communities of bacteria encased in a protective matrix.It also controls flagella formation and motility,ensuring that Vibrio spp.can move efficiently in response to environmental cues.Additionally,QS in Vibrio spp.regulates the production of different virulence factors based on cell density.This enables the bacteria to adjust their virulence strategies accordingly,enhancing pathogenicity.QS also influences the interaction between Vibrio spp.and their host.Following infection by Vibrio spp.,QS can affect the host immune response and colonization processes.Understanding the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio spp.and the host.In summary,research on QS in Vibrio spp.has revealed its significance in regulating various biological phenotypes,controlling virulence factor production and affecting host defense.It provides valuable insights into the intricate mechanisms underlying microbial behavior,host adaptation and Vibrio spp.pathogenesis.

关 键 词：quorum sensing Vibrio species biological phenotype bacterial virulence host defense 

分 类 号：R516[医药卫生—内科学]