中药有效成分对银屑病角质形成细胞凋亡的调控作用及机制的研究进展  

Research progress on regulation and mechanism of active components of traditional Chinese medicine on keratinocyte apoptosis in psoriasis

作　　者：曹爽 安月鹏[2] 刘树民[3] 杨素清[2] CAO Shuang;AN Yue-peng;LIU Shu-min;YANG Su-qing(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150000,China;Dept of Dermatology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150000,China;Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150000 [2]黑龙江中医药大学附属第一医院皮肤科,黑龙江哈尔滨150000 [3]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150000

出　　处：《中国药理学通报》2024年第9期1616-1621,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上项目(No 81973846)。

摘　　要：细胞凋亡是一种程序性细胞死亡过程,具有维持皮肤平衡的功能。在银屑病中,细胞凋亡障碍表现为角质形成细胞异常增殖。传统中药对角质形成细胞凋亡具有调控作用,以抑制银屑病表皮过度增殖、促进表皮正常分化、维护表皮稳态,且具有不良反应少、作用靶点多的优势。因此,该文对中药中多种有效成分通过干预相关因子、信号通路等以诱导银屑病角质形成细胞凋亡的具体机制进行总结分析,以期为中药治疗银屑病提供参考。Apoptosis is a process of programmed cell death,which has the function of maintaining skin balance.In psoriasis,the disturbance of apoptosis is characterized by abnormal proliferation of keratinocytes.Traditional Chinese medicine(TCM)has a regulatory effect on keratinocyte apoptosis,which can inhibit the excessive proliferation of psoriasis epidermis,promote normal epidermal differentiation,and maintain epidermal homeostasis.It has the advantages of fewer adverse reactions and multi-targets.Therefore,this article summarizes and analyzes the specific mechanism of various active ingredients of TCM to induce the apoptosis of psoriasis keratinocytes by interfering with related factors and signaling pathways,hoping to provide a reference for the treatment of psoriasis with TCM.

关 键 词：角质形成细胞 细胞凋亡 银屑病 中药有效成分 作用机制 研究进展 

分 类 号：R272.71[医药卫生—中医儿科学] R284.1[医药卫生—中医学] R329.25R758.63