黄芪代茶饮联合地特胰岛素治疗气阴两虚证妊娠期糖尿病效果研究  

Effect of Astragalus tea decoction combined with Dete insulin on gestational diabetes mellitus with Qi-Yin deficiency syndrome

作　　者：郭玉玲 李忠廉[3] Guo Yuling;Li Zhonglian(Graduate School,Tianjin Medical University,Tianjin 300070,China;Department of Obstetrical,Tianjin Central Hospital of Obstetrics and Gynecology,Tianjin 300190,China;Department of Hepatobiliary and Pancreatic Surgery,Tianjin Hospital of Integrated Traditional Chinese and Western Medicine,Tianjin 300100,China)

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市中心妇产科医院产科,天津300190 [3]天津市中西医结合医院肝胆胰外科二,天津300100

出　　处：《天津医科大学学报》2024年第5期445-448,共4页Journal of Tianjin Medical University

摘　　要：目的:分析黄芪代茶饮联合地特胰岛素治疗气阴两虚证妊娠期糖尿病的临床效果。方法:回顾性分析天津市中心妇产科医院2021年3月-2023年3月收治的60例气阴两虚证妊娠期糖尿病患者,根据治疗方案分为研究组和对照组,各30例。对照组提供地特胰岛素治疗[睡前皮下注射,0.1~0.2 U/(kg·d)],研究组提供地特胰岛素联合黄芪(10 g为1剂,每日1剂)代茶饮治疗。对比疗效和血糖指标、氧化应激指标、炎症与生长因子和妊娠结局以及治疗安全性。结果:研究组疗效、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、总抗氧化能力(T-AOC)和肝细胞生长因子(HGF)明显高于对照组,中医证候积分、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、HbA1c、炎症因子和不良妊娠结局发生率明显降低(t=0.005~15.233,均P<0.05);两组治疗安全性相当(P>0.05)。结论:黄芪代茶饮联合地特胰岛素治疗气阴两虚证妊娠期糖尿病,可减轻症状,改善不良妊娠结局。Objective:To analyze the clinical effect of Astragalus substitute tea in the treatment of gestational diabetes mellitus with Qi-Yin deficiency syndrome.Methods:Retrospective analysis of 60 cases of gestational diabetes mellitus with Qi-Yin deficiency syn-drome admitted to Tianjin Central Obstetrics and Gynecology Hospital from March 2021 to March 2023.They were divided into study group and control group according to therapeutic regimen,with 30 cases in each group.The control group was provided with Dete insulin[subcutaneous injection before going to bed,0.1-0.2 U(/kg·d)],while the study group was provided with Dete insulin combined with Astragalus(10 g as 1 dose,1 dose per day)as tea substitute.Efficacy was compared with glycemic markers,oxidative stress markers,inflammation and growth factors,and pregnancy outcomes,as well as treatment safety.Results:The efficacy,superoxide dismutase(SOD),catalase(CAT),total antioxidant capacity(T-AOC)and hepatocyte growth factor(HGF)of the study group were significantly higher than those of the control group.The incidence of TCM syndrome scores,fasting blood glucose(FPG),2 h postmeal blood glucose(2 h PG),glycated hemoglobin(HbA1c),inflammatory factors and adverse pregnancy outcomes were significantly decreased(t=0.005-15.233,all P<0.05).The treatment safety of the two groups was similar(P>0.05).Conclusion:The treatment of gestational diabetes mellitus with Qi-Yin deficiency syndrome by Astragalus tea decoction combined with Dete insulin can alleviate the symptoms and improve the adverse pregnancy outcome.

关 键 词：黄芪代茶饮 地特胰岛素 气阴两虚证 妊娠期糖尿病 

分 类 号：R714.256[医药卫生—妇产科学]