尿石净丸对尿路结石患者体外冲击波碎石术后促排石效果及复发率的影响  

The Influence of Urinary Stones-removing Pill on Stone Expulsion and Recurrence Rate after Extracorporeal Shock Wave Lithotripsy in Patients with Urinary Stones

作　　者：胡培森[1] 吴志洲 王交托 夏旭[1] 张林超[1] HU Peisen;WU Zhizhou;WANG Jiaotuo;XIA Xu;ZHANG Linchao(The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou,Henan,China,450002)

机构地区：[1]河南中医药大学第二附属医院,河南省中医院,河南郑州450002

出　　处：《河南中医》2024年第9期1402-1406,共5页Henan Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(20-21ZY2066)。

摘　　要：目的:探究尿石净丸对尿路结石患者体外冲击波碎石术(extracorporeal shock wave lithotripsy,ESWL)后促排石效果及复发率的影响。方法:将120例尿路结石患者按随机数字表法分为对照组与研究组,每组各60例。两组均行ESWL治疗,对照组术后给予常规西药治疗,研究组在对照组治疗的基础上给予尿石净丸治疗。比较两组临床疗效、结石排净及复发情况、中医证候积分、尿微量白蛋白(microalbuminuria,mAlb)、血清胱抑素C(cystatin C,Cys C)、术后并发症发生情况。结果:研究组有效率为96.49%,对照组有效率为82.76%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组术后第7天、第14天结石排净率分别为57.89%、87.72%,对照组术后第7天、第14天结石排净率分别为37.93%、70.69%,研究组结石排净率高于对照组,差异有统计学意义(P<0.05);研究组结石复发率为3.51%,对照组结石复发率为15.52%,研究组结石复发率低于对照组,差异有统计学意义(P<0.05)。研究组术后第7天中医证候积分、mAlb、Cys C低于对照组,差异有统计学意义(P<0.05)。研究组术后并发症发生率为10.53%,对照组术后并发症发生率为27.59%,研究组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:尿石净丸可提升尿路结石患者ESWL术后促排石效果,明显减少术后肾损伤,降低结石复发率及术后并发症发生率。Objective:To explore the influence of Urinary Stones-removing Pill on stone expulsion and recurrence rate after extracorporeal shock wave lithotripsy(ESWL) in patients with urinary stones.Methods:A total of 120 patients with urinary stones were randomly divided into the control and the study groups,with 60 cases in each group.Both groups received ESWL treatment.Then the control group additionally received routine Western medicine treatment,while the study group received Urinary Stones-removing Pill in addition to the control group′s treatment.The clinical efficacy,stone expulsion rate,recurrence rate,TCM syndrome scores,microalbuminuria(mAlb),serum cystatin C(Cys C),and postoperative complications were compared between the two groups.Results:The effective rate of the study group was 96.49%,higher than 82.76% of the control group,with statistical difference(P<0.05).On the 7th and 14th days after ESWL,the stone expulsion rates of the study group were 57.89% and 87.72% respectively,compared to 37.93% and 70.69% in the control group.The study group′s stone expulsion rate was significantly higher than that of the control group,with statistical difference(P<0.05).The recurrence rate in the study group was 3.51%,lower than the 15.52% in the control group,with statistical difference(P<0.05).On the 7th day after ESWL,the TCM syndrome scores,mAlb,and Cys C levels in the study group were significantly lower than those in the control group,with statistical differences(P<0.05).The postoperative complication rate in the study group was 10.53%,lower than the 27.59% in the control group,with statistical difference(P<0.05).Conclusion:Urinary Stones-removing Pill can enhance the stone expulsion effect after ESWL in patients with urinary stones,significantly reduce postoperative kidney damage,lower the recurrence rate of stones,and decrease the incidence of postoperative complications.

关 键 词：尿路结石 尿石净丸 体外冲击波碎石术 排石效果 

分 类 号：R256.52[医药卫生—中医内科学]